Document Detail


Genetic dominance influences blood biomarker levels in a sample of 12,000 Swedish elderly twins.
MedLine Citation:
PMID:  19456221     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In twin studies of cardiovascular disease biomarkers the dizygotic correlations are often estimated to be less than half of monozygotic correlations indicating a potential influence of nonadditive genetic factors. Using a large and homogenous sample, we estimated the additive and dominance genetic influences on levels of high density lipoprotein, low density lipoprotein, apolipoprotein A-I, apolipoprotein B, total cholesterol, triglycerides, glucose, hemoglobin Alc and c-reactive protein, all of which are biomarkers associated with cardiovascular disease. The blood biomarkers were measured on 12,000 Swedish twins born between 1911 and 1958. The large sample allowed us to obtain heritability estimates with considerable precision and provided adequate statistical power for estimation of dominance genetic components. Our study showed complete absence of the shared environment component for the investigated traits. Dominant genetic component was shown to be significant for low density lipoprotein (0.18), glucose (0.31), Hemoglobin Alc (0.55), and c-reactive protein (0.27). To our knowledge, this is the first statistically significant evidence for dominance genetic variance found for low density lipoprotein, glucose, hemoglobin Alc, and c-reactive protein in a population based twin sample. The study highlights the importance of acknowledging nonadditive genes underlying the risk of developing cardiovascular diseases.
Authors:
Iffat Rahman; Anna M Bennet; Nancy L Pedersen; Ulf de Faire; Per Svensson; Patrik K E Magnusson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Twin Study    
Journal Detail:
Title:  Twin research and human genetics : the official journal of the International Society for Twin Studies     Volume:  12     ISSN:  1832-4274     ISO Abbreviation:  -     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-21     Completed Date:  2009-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244624     Medline TA:  Twin Res Hum Genet     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  286-94     Citation Subset:  IM    
Affiliation:
1 Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Aged
Apolipoprotein A-I / blood,  genetics
Biological Markers / blood*
C-Reactive Protein / genetics,  metabolism
Cholesterol, HDL / blood,  genetics
Cholesterol, LDL / blood,  genetics
Female
Genes, Dominant*
Hemoglobin A, Glycosylated / genetics,  metabolism
Humans
Male
Middle Aged
Registries
Sweden
Triglycerides / blood,  genetics
Twins, Dizygotic / blood,  genetics
Twins, Monozygotic / blood,  genetics
Chemical
Reg. No./Substance:
0/Apolipoprotein A-I; 0/Biological Markers; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Hemoglobin A, Glycosylated; 0/Triglycerides; 9007-41-4/C-Reactive Protein

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