| Genetic diversity of the Kaposi's sarcoma herpesvirus K1 protein in AIDS-KS in Zimbabwe. | |
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MedLine Citation:
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PMID: 18394954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Kaposi's sarcoma-associated herpesvirus (KSHV) encodes genetically diverse K1 alleles which have unique geographic distributions. Little is known about K1 genetic diversity in Zimbabwe where acquired immunodeficiency syndrome-associated KS (AIDS-KS) is epidemic. OBJECTIVE: Evaluate K1 diversity in Zimbabwe and compare Zimbabwean K1 diversity to other areas in Africa. STUDY DESIGN: K1 nucleotide sequence was determined for AIDS-KS cases in Zimbabwe. K1 references sequences were obtained from Genbank. RESULTS: Among 65 Zimbabwean AIDS-KS cases, 26 (40%) were K1 subtype A and 39 (60%) were subtype B. Zimbabwean subtype A sequences grouped only with African intratype A5 variants. Zimbabwean subtype B sequences grouped with multiple intratype African variants: 26 B1 (26%), four B3 (6%) and nine highly divergent B4 (14%). Zimbabwean subtype B had a lower synonymous to nonsynonymous mutation ratio (median 0.59 versus 0.66; P=0.008) and greater distance to the most recent common ancestor (median 0.03 versus 0.009; P<0.001) compared to subtype A. Within the B subgroup, the distribution of intratype B variants differed in Zimbabwe and Uganda (P=0.004). CONCLUSIONS: Greater positive selection and genetic diversity in K1 subtype B compared to subtype A5 exist in Zimbabwe. However, there were no significant associations between K1 subtype and the clinical or demographic characteristics of AIDS-KS cases. |
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Authors:
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Tiffany White; Moira Hagen; Ivy Gudza; Irene E White; Buxton Ndemera; Lovemore Gwanzura; Margaret Borok; Thomas B Campbell |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-04-03 |
Journal Detail:
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Title: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology Volume: 42 ISSN: 1386-6532 ISO Abbreviation: J. Clin. Virol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-30 Completed Date: 2008-08-12 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9815671 Medline TA: J Clin Virol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 165-71 Citation Subset: IM |
Affiliation:
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Division of Infectious Diseases, Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/DQ309696; DQ309697; DQ309698; DQ309699; DQ309700; DQ309701; DQ309702; DQ309703; DQ309704; DQ309705; DQ309706; DQ309707; DQ309708; DQ309709; DQ309710; DQ309711; DQ309712; DQ309713; DQ309714; DQ309715; DQ309716; DQ309717; DQ309718; DQ309719; DQ309720; DQ309721; DQ309722; DQ309723; DQ309724; DQ309725; DQ309726; DQ309727; DQ309728; DQ309729; DQ309730; DQ309731; DQ309732; DQ309733; DQ309734; DQ309735; DQ309736; DQ309737; DQ309738; DQ309739; DQ309740; DQ309741; DQ309742; DQ309743; DQ309744; DQ309745; DQ309746; DQ309747; DQ309748; DQ309749; DQ309750; DQ309751; DQ309752; DQ309753; DQ309754; DQ309755; DQ309756; DQ309757; DQ309758; DQ309759; DQ309760; DQ309761; DQ309762 |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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epidemiology,
virology Genetic Variation* Genotype Herpesvirus 8, Human / classification, genetics* Humans Molecular Sequence Data Phylogeny Sarcoma, Kaposi / epidemiology*, virology Sequence Analysis, DNA Uganda / epidemiology Viral Proteins / chemistry, genetics* Zimbabwe / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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5T32AI07537-04/AI/NIAID NIH HHS; AI-07447/AI/NIAID NIH HHS; P30 AI054907/AI/NIAID NIH HHS; P30 CA046934/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/K1 protein, Human herpesvirus 8; 0/Viral Proteins |
| Comments/Corrections | |
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