Document Detail


Genetic dissociation of multiple morphine effects among C57BL/6J, DBA/2J and C3H/HeJ inbred mouse strains.
MedLine Citation:
PMID:  2813556     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pattern of sensitivity of mice from three inbred strains were compared on measures of morphine-induced analgesia (hot plate), locomotor activity, hypothermia, Straub tail (muscular rigidity), antidiuresis and constipation. The DBA/2J strain emerged as the most sensitive strain for analgesia, retention of a water load (antidiuresis) and hypothermia. In addition, the DBA/2J mice had lower concentrations of morphine in the brain 30 min after injection and had the lowest Kd and the highest Bmax for naloxone as measured by in vitro receptor binding. In contrast, mice of the C57BL/6J strain were most sensitive when locomotor activity, Straub tail and constipation were measured. The C3H/HeJ mice were generally intermediate in their sensitivity to morphine. The observed strain differences indicate a rather high degree of genetic control for most of the effects studied, however, the low consistency of rank order among the three strains across these measures suggests that the genetically determined mechanisms are largely different between these measures of morphine sensitivity.
Authors:
J K Belknap; B Noordewier; M Lamé
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  46     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-12-21     Completed Date:  1989-12-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  69-74     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, School of Medicine, University of North Dakota, Grand Forks 58202.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arousal / drug effects*
Behavior, Animal / drug effects*
Body Temperature Regulation / drug effects
Diuresis / drug effects
Dose-Response Relationship, Drug
Genotype*
Male
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Inbred DBA
Morphine / pharmacology*
Motor Activity / drug effects
Muscle Contraction / drug effects
Nociceptors / drug effects*
Reaction Time / drug effects
Species Specificity*
Grant Support
ID/Acronym/Agency:
NIDA 02351/DA/NIDA NIH HHS; NIDA 02723/DA/NIDA NIH HHS; NIDA 271-87-8020/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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