Document Detail


Genetic disruption of protein phosphatase 5 in mice prevents high-fat diet feeding-induced weight gain.
MedLine Citation:
PMID:  24220247     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The role of serine/threonine protein phosphatase 5 (PP5) in the development of obesity and insulin resistance associated with high-fat diet-feeding (HFD) was examined using PP5-deficient mice (Ppp5c(-/-)). Despite similar caloric intake, Ppp5c(-/-) mice on HFD gained markedly less weight and did not accumulate visceral fat compared to wild-type littermates (Ppp5c(+/+)). On a control diet, Ppp5c(-/-) mice had markedly improved glucose control compared to Ppp5c(+/+) mice, an effect diminished by HFD. However, even after 10weeks of HFD glucose control in Ppp5c(-/-) mice was similar to that observed in Ppp5c(+/+) mice on the control diet. Thus, PP5 deficiency confers protection against HFD-induced weight gain in mice.
Authors:
N Grankvist; R E Honkanen; A Sjöholm; H Ortsäter
Related Documents :
11206867 - Effect of rotavirus infection on lipid composition and glucose uptake in infant mouse i...
23028137 - Portal vein glucose entry triggers a coordinated cellular response that potentiates hep...
25024607 - High fat diet feeding results in gender specific steatohepatitis and inflammasome activ...
24746977 - Physical exercise antagonizes clinical and anatomical features characterizing lieber-de...
2351867 - Lovastatin therapy reduces low density lipoprotein apob levels in subjects with combine...
14767247 - Factors related to rapid weight loss practices among international-style wrestlers.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-26
Journal Detail:
Title:  FEBS letters     Volume:  -     ISSN:  1873-3468     ISO Abbreviation:  FEBS Lett.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Affiliation:
Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden. Electronic address: ngrankvist@sbmri.org.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes t...
Next Document:  I think I can't: Drink refusal self-efficacy as a mediator of the relationship between self-reported...