Document Detail


Genetic differences in androgen receptors and in autoregulation of testicular human chorionic gonadotropin binding sites in the mouse.
MedLine Citation:
PMID:  6417328     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The autoregulation of testicular human chorionic gonadotropin (hCG) binding sites was studied in two strains of mice known to differ in their endocrine and reproductive characteristics (C57BL/10J and DBA/2J), and in their F1 progeny (B10D2F1). Basal hCG binding levels were higher in C57BL/10J than in DBA/2J mice, while B10D2F1 mice had intermediate levels. Twenty-four h after injection, hCG produced dose-related changes in hCG binding in C57BL/10J and B10D2F1 mice not observed in DBA/2J mice. However, 72 h after treatment with hCG there was a decrease in hCG binding in all the strains studied. These results suggest the participation of genetic factors in determining basal levels, dose-related changes and temporal response of testicular hCG binding sites to hCG administration. Androgen receptor levels were measured in the same strains of mice. DBA/2J mice had higher receptor levels in the kidney and coagulating gland, and lower levels in the hypothalamus and seminal vesicle when compared to C57BL/10J mice. B10D2F1 mice had androgen receptor levels similar to those measured in C57BL/10J mice in all tissues studied, with the exception of the coagulating gland, where levels were similar to those observed in DBA/2J mice. These observations may indicate the existence of several loci coding for androgen receptors, with only one being expressed per tissue.
Authors:
A G Amador; A Bartke; T A Parkening; G C Chamness
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of receptor research     Volume:  3     ISSN:  0197-5110     ISO Abbreviation:  J. Recept. Res.     Publication Date:  1983  
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008358     Medline TA:  J Recept Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  495-512     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Binding Sites
Chorionic Gonadotropin / pharmacology*
Follicle Stimulating Hormone / blood
Homeostasis
Kidney / analysis
Luteinizing Hormone / blood
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Prolactin / blood
Receptors, Androgen / analysis,  genetics*
Receptors, Steroid / genetics*
Seminal Vesicles / analysis
Testis / physiology*
Testosterone / blood
Grant Support
ID/Acronym/Agency:
HD 12642/HD/NICHD NIH HHS; P30 HD 10202/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Receptors, Androgen; 0/Receptors, Steroid; 58-22-0/Testosterone; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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