| Genetic development of an inbred rat strain with increased resistance adaptation to a hot environment. | |
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MedLine Citation:
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PMID: 8238471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to demonstrate resistance adaptation based on genotypic adaptation and to develop an inbred rat strain with genotypic resistance adaptation to a hot environment. Survival time (ST) at an ambient temperature (Ta) of 42.5 degrees C was determined without appreciable thermal damage. Rats with the longest ST were sibmated over 30 generations and designated FOK. The ST, evaporative water loss, and body water economy increased rapidly during the first 10-15 generations, followed by a more gradual increase. The FOK rat resisted a Ta of 42.5 degrees C for > 5 h; this ability was hereditary. Body size progressively decreased during the early generations. The ST was longer (P < 0.01) and evaporative water loss was significantly higher (P < 0.01) in the FOK rat compared with three other strains. Tail lengths in the FOK rat were slightly shorter than those of three controls (P < 0.01). The heat loss system in the FOK rat may depend on the ability to mobilize and evaporate body fluids efficiently. FOK rats can be used for phenotypic comparisons with other strains, as well as in molecular genetic studies on thermoregulation, osmoregulation, and resistance adaptation to heat using recombinant inbred and recombinant congenic lines. |
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Authors:
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F Furuyama; K Ohara |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 265 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1993-12-01 Completed Date: 1993-12-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R957-62 Citation Subset: IM |
Affiliation:
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Department of Physiology, Nagoya City University Medical School, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization* Animals Body Constitution Body Temperature Regulation Body Water / metabolism Environment* Female Genotype Hot Temperature* Male Rats Rats, Inbred Strains / genetics*, physiology* Survival Analysis Water Loss, Insensible |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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