| Genetic determinants of von Willebrand factor levels and activity in relation to the risk of cardiovascular disease: a review. | |
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MedLine Citation:
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PMID: 21342431 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is well established that high plasma von Willebrand factor (VWF) levels are associated with an increased risk of arterial thrombosis, including myocardial infarction and ischemic stroke. As plasma VWF levels are, to a large extent, genetically determined, numerous association studies have been performed to assess the effect of genetic variability in the VWF gene (VWF) on VWF antigen and activity levels, and on the risk of arterial thrombosis. Genetic variations in other regulators of VWF, including the ABO blood group, ADAMTS-13, thrombospondin-1 and the recently identified SNARE protein genes, have also been investigated. In this article, we review the current literature as exploring the associations between genetic variations and the risk of arterial thrombosis may help elucidate the role of VWF in the pathogenesis of arterial thrombosis. However, as studies frequently differ in design, population and endpoint, and are often underpowered, it remains unclear whether VWF is causally related to the occurrence of arterial thrombosis or primarily mirrors endothelial dysfunction, which predisposes to atherosclerosis and subsequent arterial thrombosis. Nevertheless, current studies provide interesting results that do not exclude the possibility of VWF as causal mediator and justify further research into the relationship between VWF and arterial thrombosis. Large prospective studies are required to further establish the role of VWF in the occurrence of arterial thrombosis. |
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Authors:
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M C van Schie; J E van Loon; M P M de Maat; F W G Leebeek |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of thrombosis and haemostasis : JTH Volume: 9 ISSN: 1538-7836 ISO Abbreviation: J. Thromb. Haemost. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-10 Completed Date: 2011-10-03 Revised Date: 2011-11-28 |
Medline Journal Info:
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Nlm Unique ID: 101170508 Medline TA: J Thromb Haemost Country: England |
Other Details:
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Languages: eng Pagination: 899-908 Citation Subset: IM |
Copyright Information:
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© 2011 International Society on Thrombosis and Haemostasis. |
Affiliation:
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Department of Haematology, Erasmus University Medical Centre, Rotterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ABO Blood-Group System ADAM Proteins / biosynthesis Adult Aged Arteries / pathology Cardiovascular Diseases / diagnosis*, genetics* Genetic Variation Humans Ischemia / pathology Middle Aged Models, Genetic Myocardial Infarction / diagnosis, pathology Polymorphism, Single Nucleotide Risk Stroke / genetics, pathology Thrombosis / pathology Thrombospondin 1 / biosynthesis von Willebrand Factor / biosynthesis, genetics* |
| Chemical | |
Reg. No./Substance:
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0/ABO Blood-Group System; 0/Thrombospondin 1; 0/von Willebrand Factor; EC 3.4.24.-/ADAM Proteins; EC 3.4.24.-/ADAMTS13 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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