Document Detail


Genetic determinants of voluntary exercise.
MedLine Citation:
PMID:  23351966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Variation in voluntary exercise behavior is an important determinant of long-term human health. Increased physical activity is used as a preventative measure or therapeutic intervention for disease, and a sedentary lifestyle has generally been viewed as unhealthy. Predisposition to engage in voluntary activity is heritable and induces protective metabolic changes, but its complex genetic/genomic architecture has only recently begun to emerge. We first present a brief historical perspective and summary of the known benefits of voluntary exercise. Second, we describe human and mouse model studies using genomic and transcriptomic approaches to reveal the genetic architecture of exercise. Third, we discuss the merging of genomic information and physiological observations, revealing systems and networks that lead to a more complete mechanistic understanding of how exercise protects against disease pathogenesis. Finally, we explore potential regulation of physical activity through epigenetic mechanisms, including those that persist across multiple generations.
Authors:
Scott A Kelly; Daniel Pomp
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-01-23
Journal Detail:
Title:  Trends in genetics : TIG     Volume:  29     ISSN:  0168-9525     ISO Abbreviation:  Trends Genet.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-27     Completed Date:  2013-11-25     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  8507085     Medline TA:  Trends Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  348-57     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Epigenesis, Genetic
Exercise*
Gene Expression
Gene Regulatory Networks
Genetic Determinism*
Genome-Wide Association Study
Humans
Quantitative Trait Loci
Grant Support
ID/Acronym/Agency:
DK056350/DK/NIDDK NIH HHS; DK076050/DK/NIDDK NIH HHS; P30 DK056350/DK/NIDDK NIH HHS; R01 DK076050/DK/NIDDK NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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