| Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China. | |
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MedLine Citation:
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PMID: 19888660 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the associations between 21 single nucleotide polymorphisms (SNPs) of eight lipid metabolism genes and lipid levels in a Chinese population. This study was conducted as part of a population-based study in China with 799 randomly selected healthy residents who provided fasting blood and an in-person interview. Associations between variants and mean lipid levels were examined using a test of trend and least squares mean test in a general linear model. Four SNPs were associated with lipid levels: LDLR rs1003723 was associated with total cholesterol (P-trend = 0.002) and LDL (P-trend = 0.01), LDLR rs6413503 was associated with total cholesterol (P-trend = 0.05), APOB rs1367117 was associated with apoB (P-trend = 0.02), and ABCB11 rs49550 was associated with total cholesterol (P-trend = 0.01), triglycerides (P-trend = 0.01), and apoA (P-trend = 0.01). We found statistically significant effects on lipid levels for LDLR rs6413503 among those with high dairy intake, LPL rs263 among those with high allium vegetable intake, and APOE rs440446 among those with high red meat intake. We identified new associations between SNPs and lipid levels in Chinese previously found in Caucasians. These findings provide insight into the role of lipid metabolism genes, as well as the mechanisms by which these genes may be linked with disease. |
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Authors:
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Gabriella Andreotti; Idan Menashe; Jinbo Chen; Shih-Chen Chang; Asif Rashid; Yu-Tang Gao; Tian-Quan Han; Lori C Sakoda; Stephen Chanock; Philip S Rosenberg; Ann W Hsing |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural Date: 2009-11-04 |
Journal Detail:
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Title: European journal of epidemiology Volume: 24 ISSN: 1573-7284 ISO Abbreviation: Eur. J. Epidemiol. Publication Date: 2009 |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-04-13 Revised Date: 2010-09-28 |
Medline Journal Info:
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Nlm Unique ID: 8508062 Medline TA: Eur J Epidemiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 763-74 Citation Subset: IM |
Affiliation:
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Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, 6120 Executive Blvd., EPS 8011, MSC 7240, Bethesda, MD, 20892, USA. andreotg@mail.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ATP-Binding Cassette Transporters
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genetics Adult Aged Apolipoproteins B / genetics China Female Humans Hyperlipidemias / genetics* LDL-Receptor Related Proteins / genetics Lipids / blood*, genetics Male Middle Aged Polymorphism, Single Nucleotide Population Surveillance* |
| Grant Support | |
ID/Acronym/Agency:
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ZIA CP010158-09/CP/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/ABCB11 protein, human; 0/ATP-Binding Cassette Transporters; 0/Apolipoproteins B; 0/LDL-Receptor Related Proteins; 0/Lipids |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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