Document Detail


Genetic determinants of cholestasis.
MedLine Citation:
PMID:  23540495     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Cholestasis is an overarching term applied for conditions whereby biliary constituents are found in the circulation because of impairment to bile flow. A variety of processes can lead to cholestasis, be they acute or chronic injuries to hepatocytes, cholangiocytes, or the broader biliary tree itself. Such injuries may be driven by rare but highly informative primary genetic abnormalities, or may be seen in individuals with a prior genetic predisposition when confronted by specific environmental challenges such as drug exposure. This review provides a broad outline of some fundamental primary genetic cholestatic syndromes and an update on varying genetic predisposition underlying several acquired cholestatic processes.
Authors:
Gideon M Hirschfield
Related Documents :
20972165 - Ponm04 myofibrillar myopathy caused by a mutation in the desmin gene: expanding the phe...
15716625 - A korean family of hypokalemic periodic paralysis with mutation in a voltage-gated calc...
15381555 - A novel elastin gene mutation resulting in an autosomal dominant form of cutis laxa.
23533235 - Allele percentage of the braf v600e mutation in papillary thyroid carcinomas and corres...
22825795 - Benign hereditary chorea: dopaminergic brain imaging in patients with a novel intronic ...
16753275 - Allele frequency distribution based on 17 str markers in three major dravidian linguist...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics in liver disease     Volume:  17     ISSN:  1557-8224     ISO Abbreviation:  Clin Liver Dis     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9710002     Medline TA:  Clin Liver Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  147-59     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Affiliation:
NIHR Biomedical Research Unit and Centre for Liver Research, Institute of Biomedical Research, The Medical School, University of Birmingham, Wolfson Drive, Birmingham B15 2TT, UK. Electronic address: g.hirschfield@bham.ac.uk.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Feasibility of an online adaptive replanning method for cranial frameless intensity-modulated radios...
Next Document:  Nuclear receptors as drug targets in cholestatic liver diseases.