Document Detail

Genetic determinants of cholestasis.
MedLine Citation:
PMID:  23540495     Owner:  NLM     Status:  In-Data-Review    
Cholestasis is an overarching term applied for conditions whereby biliary constituents are found in the circulation because of impairment to bile flow. A variety of processes can lead to cholestasis, be they acute or chronic injuries to hepatocytes, cholangiocytes, or the broader biliary tree itself. Such injuries may be driven by rare but highly informative primary genetic abnormalities, or may be seen in individuals with a prior genetic predisposition when confronted by specific environmental challenges such as drug exposure. This review provides a broad outline of some fundamental primary genetic cholestatic syndromes and an update on varying genetic predisposition underlying several acquired cholestatic processes.
Gideon M Hirschfield
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics in liver disease     Volume:  17     ISSN:  1557-8224     ISO Abbreviation:  Clin Liver Dis     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9710002     Medline TA:  Clin Liver Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  147-59     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
NIHR Biomedical Research Unit and Centre for Liver Research, Institute of Biomedical Research, The Medical School, University of Birmingham, Wolfson Drive, Birmingham B15 2TT, UK. Electronic address:
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