Document Detail


Genetic determinants of blood pressure regulation.
MedLine Citation:
PMID:  16269952     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertension is a multifactorial disorder that probably results from the inheritance of a number of susceptibility genes and involves multiple environmental determinants. Existing evidence suggests that the genetic contribution to blood pressure variation is about 30-50%. Although a number of candidate genes have been studied in different ethnic populations, results from genetic analysis are still inconsistent and specific causes of hypertension remain unclear. Furthermore, the abundance of data in the literature makes it difficult to piece together the puzzle of hypertension and to define candidate genes involved in the dynamic of blood pressure regulation. In this review, we attempt to highlight the genetic basis of hypertension pathogenesis, focusing on the most important existing genetic variations of candidate genes and their potential role in the development of this disease. Our objective is to review current knowledge and discuss limitations to clinical applications of genotypic information in the diagnosis, evaluation and treatment of hypertension. Finally, some principles of pharmacogenomics are presented here along with future perspectives of hypertension.
Authors:
Jean-Brice Marteau; Mohamed Zaiou; Gérard Siest; Sophie Visvikis-Siest
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of hypertension     Volume:  23     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-04     Completed Date:  2006-03-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  2127-43     Citation Subset:  IM    
Affiliation:
INSERM U525, Equipe 4, Faculté de Pharmacie, Université Henri Poincare, Nancy, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrial Natriuretic Factor / genetics
Blood Pressure / drug effects,  genetics*
Cytokines / genetics
Endothelins / genetics
Epithelial Sodium Channel
Genetic Variation
Humans
Hypertension / drug therapy,  etiology,  genetics*,  physiopathology*
Models, Cardiovascular
Pharmacogenetics
Receptors, Adrenergic, beta / genetics
Renin-Angiotensin System / genetics
Signal Transduction / genetics
Sodium / metabolism
Sodium Channels / genetics
Chemical
Reg. No./Substance:
0/Cytokines; 0/Endothelins; 0/Epithelial Sodium Channel; 0/Receptors, Adrenergic, beta; 0/Sodium Channels; 7440-23-5/Sodium; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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