| Genetic determinants of blood pressure regulation. | |
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MedLine Citation:
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PMID: 16269952 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension is a multifactorial disorder that probably results from the inheritance of a number of susceptibility genes and involves multiple environmental determinants. Existing evidence suggests that the genetic contribution to blood pressure variation is about 30-50%. Although a number of candidate genes have been studied in different ethnic populations, results from genetic analysis are still inconsistent and specific causes of hypertension remain unclear. Furthermore, the abundance of data in the literature makes it difficult to piece together the puzzle of hypertension and to define candidate genes involved in the dynamic of blood pressure regulation. In this review, we attempt to highlight the genetic basis of hypertension pathogenesis, focusing on the most important existing genetic variations of candidate genes and their potential role in the development of this disease. Our objective is to review current knowledge and discuss limitations to clinical applications of genotypic information in the diagnosis, evaluation and treatment of hypertension. Finally, some principles of pharmacogenomics are presented here along with future perspectives of hypertension. |
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Authors:
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Jean-Brice Marteau; Mohamed Zaiou; Gérard Siest; Sophie Visvikis-Siest |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of hypertension Volume: 23 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-11-04 Completed Date: 2006-03-02 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 2127-43 Citation Subset: IM |
Affiliation:
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INSERM U525, Equipe 4, Faculté de Pharmacie, Université Henri Poincare, Nancy, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrial Natriuretic Factor / genetics Blood Pressure / drug effects, genetics* Cytokines / genetics Endothelins / genetics Epithelial Sodium Channel Genetic Variation Humans Hypertension / drug therapy, etiology, genetics*, physiopathology* Models, Cardiovascular Pharmacogenetics Receptors, Adrenergic, beta / genetics Renin-Angiotensin System / genetics Signal Transduction / genetics Sodium / metabolism Sodium Channels / genetics |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Endothelins; 0/Epithelial Sodium Channel; 0/Receptors, Adrenergic, beta; 0/Sodium Channels; 7440-23-5/Sodium; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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