Document Detail


Genetic determinant of intrinsic quinolone resistance in Fusobacterium canifelinum.
MedLine Citation:
PMID:  15616329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fourteen fluoroquinolone-resistant fusobacterial strains, originating from cats or dogs, were characterized by sequencing of the 16S-23S and 16S rRNA genes and DNA-DNA hybridization and were described as a new species, Fusobacterium canifelinum. All of the strains are intrinsically resistant (MIC, >4 g/ml) to levofloxacin and other fluoroquinolones. Compared to the quinolone resistance-determining region (gyrA) of the susceptible relative F. nucleatum, we found that Ser79 was replaced with leucine and Gly83 was replaced with arginine.
Authors:
Georg Conrads; Diane M Citron; Ellie J C Goldstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  49     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-23     Completed Date:  2005-02-22     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  434-7     Citation Subset:  IM    
Affiliation:
Division of Oral Microbiology and Immunology University Hospital, Pauwelsstrasse 30, D-52057 Aachen, Germany. gconrads@ukaachen.de
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AY660893;  AY660896
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Anti-Infective Agents / pharmacology*
Base Sequence
Cat Diseases / microbiology
Cats
DNA Gyrase / chemistry,  genetics*
Dog Diseases / microbiology
Dogs
Drug Resistance, Bacterial / genetics*
Fluoroquinolones / pharmacology*
Fusobacterium / classification,  drug effects*,  genetics,  isolation & purification
Fusobacterium Infections / microbiology,  veterinary*
Microbial Sensitivity Tests
Molecular Sequence Data
Sequence Analysis, DNA
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Fluoroquinolones; EC 5.99.1.-/DNA Gyrase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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