| Genetic deficiency of apolipoprotein D in the mouse is associated with nonfasting hypertriglyceridemia and hyperinsulinemia. | |
| | |
MedLine Citation:
|
PMID: 21632073 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Apolipoprotein D (ApoD) is an atypical apolipoprotein with an incompletely understood function in the regulation of triglyceride and glucose metabolism. We have demonstrated that elevated ApoD production in mice results in improved postprandial triglyceride clearance. This work studies the role of ApoD deficiency in the regulation of triglyceride and glucose metabolism and its dependence on aging. We used ApoD knockout (ApoD-KO) mice of 3 and 21 months of age. Body weight and food intake were measured. Hepatic histology, triglyceride content, lipoprotein lipase levels, and plasma metabolites were studied. Phenotypic characterization of glucose metabolism was performed using glucose tolerance test. β-Cell mass, islet volume, and islet number were analyzed by histomorphometry. Apolipoprotein D deficiency results in nonfasting hypertriglyceridemia in young (P = .01) and aged mice (P = .002). In young ApoD-KO mice, hypertriglyceridemia was associated with 30% to 50% increased food intake in nonfasting and fasting conditions, respectively, without changes in body weight. In addition, lipoprotein lipase levels were reduced by 35% in adipose tissue (P = .006). In aged ApoD-KO mice, hypertriglyceridemia was not associated with changes in food intake or body weight, whereas hepatic triglyceride levels were reduced by 35% (P = .02). Furthermore, nonfasting plasma insulin levels were elevated by 2-fold in young (P = .016) and aged (P = .004) ApoD-KO mice, without changes in blood glucose levels, glucose tolerance, β-cell mass, or islet number. These findings underscore the importance of ApoD in the regulation of plasma insulin levels and triglyceride metabolism, suggesting that ApoD plays an important role in the pathogenesis of dyslipidemia. |
| | |
Authors:
|
Margarita Jiménez-Palomares; Irene Cózar-Castellano; María Dolores Ganfornina; Diego Sánchez; Germán Perdomo |
Related Documents
:
|
22121883 - α-lipoic acid prevents mild portal endotoxaemia-induced hepatic inflammation and β ce... 23683663 - Elevated liver enzymes in individuals with undiagnosed diabetes in the u.s. 6853683 - Use of oral calcium loading to characterize the hypercalciuria of young insulin-depende... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-30 |
Journal Detail:
|
Title: Metabolism: clinical and experimental Volume: - ISSN: 1532-8600 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-6-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375267 Medline TA: Metabolism Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Hospital Universitario Puerta del Mar, Unidad de Investigación, Cádiz, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Impaired adrenergic- and corticotropic-axis outflow during exercise in chronic obstructive pulmonary...
Next Document: Serum adiponectin levels and tissue expression of adiponectin receptors are associated with risk, st...