| Genetic correlation of blood pressure responses to dietary sodium and potassium intervention and cold pressor test in chinese population. | |
| | |
MedLine Citation:
|
PMID: 20861867 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
We examined the genetic association between blood pressure (BP) responses to dietary sodium and potassium intervention and to cold pressor test (CPT) in a large family-based dietary feeding study. The dietary intervention and CPT were conducted among 1906 participants in rural China. The dietary intervention included three 7-day periods of low-sodium feeding (51.3 mmol per day), high-sodium feeding (307.8 mmol per day) and high-sodium feeding plus potassium supplementation (60 mmol per day). BP responses to high-sodium intervention had strong genetic correlations (ρ(G)) with both BP responses to low sodium (ρ(G)=-0.43 to -0.54, P-values=0.0005 to 0.03) and to potassium supplementation (ρ(G)=-0.41 to -0.49, P-values=0.001 to 0.005) interventions. Most environmental correlations between BP responses to various dietary interventions were significant. The ρ(G) between BP responses to CPT and to high-sodium intervention and potassium supplementation were statistically significant. For example, the ρ(G) between maximum BP responses to CPT and BP responses to high-sodium intervention was 0.37 (P=0.006) for systolic BP (SBP) and 0.41 (P=0.002) for diastolic BP (DBP). The ρ(G) between maximum BP responses to CPT and BP responses to potassium intervention was -0.42 (P=0.001) for SBP and -0.46 (P=0.001) for SBP. Our study suggests that there are common genetic determinants that influence BP responses to dietary sodium and potassium interventions and to CPT. |
| | |
Authors:
|
H Mei; T K Rice; D Gu; J E Hixson; C E Jaquish; Qi Zhao; J-C Chen; J Cao; J Li; T N Kelly; D C Rao; J He |
Related Documents
:
|
16484177 - Blood pressure response to 1-month, electrolyte-carbohydrate beverage consumption. 148727 - The influence of different sodium loads on renin release in hypertensive and normotensi... 2896877 - Raised venous pressure: a direct cause of renal sodium retention in oedema? 1936807 - Abnormal sympathetic and renal response to sodium restriction in compensated cirrhosis. 8937797 - Non-invasive evaluation of sympathovagal balance in athletes by time and frequency doma... 6807847 - Bacterial adherence to urothelium following bladder irrigation in the rat. |
Publication Detail:
|
Type: Journal Article Date: 2010-09-23 |
Journal Detail:
|
Title: Journal of human hypertension Volume: 25 ISSN: 1476-5527 ISO Abbreviation: J Hum Hypertens Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-07-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8811625 Medline TA: J Hum Hypertens Country: England |
Other Details:
|
Languages: eng Pagination: 500-8 Citation Subset: IM |
Affiliation:
|
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular de...
Next Document: Uric acid and fibrinogen: age-modulated relationships with blood pressure components.