| Genetic correlates of early accelerated infant growth associated with juvenile-onset type 1 diabetes. | |
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MedLine Citation:
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PMID: 21933315 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Kharagjitsingh AV, de Ridder MAJ, Alizadeh BZ, Veeze HJ, Bruining GJ, Roep BO, Koeleman BPC. Genetic correlates of early accelerated infant growth associated with juvenile-onset type 1diabetes. Objective: We previously showed that accelerated growth predisposing to development of childhood-onset type 1 diabetes (T1D) is restricted to the first year after birth. We assessed whether this phenomenon of increased early growth is associated with variants of two genes, insulin-like growth factor-1 (IGF1) and insulin variable number of tandem repeats (INS-VNTR), whose products are components of the growth axis. Patients and methods: Patients and their siblings were genotyped for the INS-VNTR and for an IGF1 microsatellite. We tested for difference in first year growth, i.e., increased weight standard deviation score (SDS), a reliable measure of especially first year growth, between carriers and non-carriers of these gene variants, using a repeated measurement and regression analysis. Results: In patients, growth did not differ between carriers and non-carriers of the INS-VNTR*III allele, while carriership of this allele in siblings was positively associated with increased first year growth. In both patients and siblings, non-carriership of the IGF1*194 allele was positively associated with growth. Birth size was not associated with either variant. Conclusions/discussion: Non-carriership of the IGF1*194 allele was positively associated with accelerated first year growth in both patients and siblings, independent of disease. This IGF1 variant may therefore contribute to increased first year growth, but cannot explain the association of first year growth with diabetes. An effect on growth of the INS-VNTR was detected in healthy siblings, but not in patients, suggesting that disease supersedes a growth effect of INS-VNTR. |
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Authors:
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Av Kharagjitsingh; Maj de Ridder; Bz Alizadeh; Hj Veeze; Gj Bruining; Bo Roep; Bobby Pc Koeleman |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-20 |
Journal Detail:
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Title: Pediatric diabetes Volume: - ISSN: 1399-5448 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100939345 Medline TA: Pediatr Diabetes Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Department of Paediatrics, Erasmus University Medical Centre/Sophia Children's Hospital, Rotterdam, The Netherlands Department of Immunohaematology & Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands Department of Internal Medicine, Medical Centre Haaglanden Westeinde, The Hague, The Netherlands Department of Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands Dutch Growth Research Foundation, Rotterdam, The Netherlands Department of Medical Genetics, University Medical Center, Utrecht, The Netherlands Diabetes Centre for Paediatric and Adolescent Diabetes, Rotterdam, The Netherlands. |
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