Document Detail


Genetic control of temperature preference in the nematode Caenorhabditis elegans.
MedLine Citation:
PMID:  15654086     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Animals modify behavioral outputs in response to environmental changes. C. elegans exhibits thermotaxis, where well-fed animals show attraction to their cultivation temperature on a thermal gradient without food. We show here that feeding-state-dependent modulation of thermotaxis is a powerful behavioral paradigm for elucidating the mechanism underlying neural plasticity, learning, and memory in higher animals. Starved experience alone could induce aversive response to cultivation temperature. Changing both cultivation temperature and feeding state simultaneously evoked transient attraction to or aversion to the previous cultivation temperature: recultivation of starved animals with food immediately induced attraction to the temperature associated with starvation, although the animals eventually exhibited thermotaxis to the new temperature associated with food. These results suggest that the change in feeding state quickly stimulates the switch between attraction and aversion for the temperature in memory and that the acquisition of new temperature memory establishes more slowly. We isolated aho (abnormal hunger orientation) mutants that are defective in starvation-induced cultivation-temperature avoidance. Some aho mutants responded normally to changes in feeding state with respect to locomotory activity, implying that the primary thermosensation followed by temperature memory formation remains normal and the modulatory aspect of thermotaxis is specifically impaired in these mutants.
Authors:
Akiko Mohri; Eiji Kodama; Koutarou D Kimura; Mizuho Koike; Takafumi Mizuno; Ikue Mori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-01-16
Journal Detail:
Title:  Genetics     Volume:  169     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-29     Completed Date:  2005-08-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1437-50     Citation Subset:  IM    
Affiliation:
Group of Molecular Neurobiology, Graduate School of Science, Nagoya University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acclimatization / drug effects,  genetics*
Animal Feed
Animals
Caenorhabditis elegans / drug effects,  genetics*,  growth & development
Feeding Behavior
Methyl Methanesulfonate / pharmacology
Movement / drug effects,  physiology
Mutagens / pharmacology
Mutation
Serotonin / pharmacology
Temperature*
Chemical
Reg. No./Substance:
0/Mutagens; 50-67-9/Serotonin; 66-27-3/Methyl Methanesulfonate
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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