Document Detail

Genetic control of the target structures recognized in hybrid resistance.
MedLine Citation:
PMID:  3301648     Owner:  NLM     Status:  MEDLINE    
Hybrid resistance of lethally irradiated (C57BL/6 X DBA/2)F1 and (C57BL/10 X C3H)F1 hybrid mice to the engraftment of parental C57BL/6 or C57BL/10 bone marrow cells is controlled by the H-2-linked Hh-1 locus. This resistance can be specifically blocked or inhibited by the injection of irradiated spleen cells from lethally irradiated, marrow reconstituted donor mice of certain strains. By testing the ability of regenerating spleen cells from various donor strains to block the resistance, we studied the genetic requirements for the expression of putative cell-surface structures recognized in hybrid resistance to H-2b marrow cells. Strains of mice bearing informative intra-H-2 or H-2/Qa-Tla recombinant haplotypes provided evidence that the Hh-1 locus is located telomeric to the H-2S region complement loci and centromeric to the H-2D region class I locus in the H-2b chromosome. Two mutations that affect the class I H-2Db gene have no effect on Hh-1b gene expression. The H-2D region of the H-2s haplotype contains an allele of the Hh-1 locus indistinguishable from that of the H-2Db region, as judged by the phenotypes of relevant strains and F1 hybrids. Collectively these data indicate that the Hh-1 locus is distinct from the class I H-2D (L) locus in the H-2b or H-2s genome, and favor the view that the expression or recognition of the relevant determinants is not associated with class I gene products.
J P Daley; J M Wroblewski; S G Kaminsky; I Nakamura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Immunogenetics     Volume:  26     ISSN:  0093-7711     ISO Abbreviation:  Immunogenetics     Publication Date:  1987  
Date Detail:
Created Date:  1987-09-16     Completed Date:  1987-09-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0420404     Medline TA:  Immunogenetics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  21-30     Citation Subset:  IM    
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MeSH Terms
Bone Marrow Transplantation*
Chromosome Mapping
Graft vs Host Reaction
H-2 Antigens / genetics*
Idoxuridine / metabolism
Immune Tolerance*
Mice, Inbred Strains
Transplantation, Isogeneic
Grant Support
Reg. No./Substance:
0/H-2 Antigens; 54-42-2/Idoxuridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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