Document Detail


Genetic control of primary neuronal development in zebrafish.
MedLine Citation:
PMID:  1842357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During the first day of embryogenesis in the zebrafish, a precise and relatively simple network of neurons develops, pioneering axonal pathways and apparently functioning to mediate reflexive motor responses to touch stimuli. We have begun to use zygotic lethal mutations to analyze the assembly of this 'primary' embryonic nervous system. Here we focus on spinal primary motoneurons, their inputs from hindbrain Mauthner neurons, and their outputs to segmental body wall muscle. The mutation nic-1 blocks synaptic transmission between nerve and muscle, yet embryonic primary motoneurons appear normal, suggesting that functional interactions with their targets are not involved in regulating their development. The mutation spt-1 directly disrupts development of this muscle, and the mutation cyc-1 appears to directly block specification of the floor plate. Both spt-1 and cyc-1 affect aspects of primary neuronal development, and they probably do so indirectly. The nonautonomous actions of these mutations are local and they produce variable neuronal phenotypes. The observations can be interpreted to mean that some cellular interactions that specify the neurons and their axonal paths occur at close range and involve multiple, possibly combinatorial, transmitter-independent pathways.
Authors:
C B Kimmel; K Hatta; J S Eisen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  Suppl 2     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1991  
Date Detail:
Created Date:  1993-01-04     Completed Date:  1993-01-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  47-57     Citation Subset:  IM    
Affiliation:
Institute of Neuroscience, University of Oregon, Eugene 97403.
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MeSH Terms
Descriptor/Qualifier:
Animals
Embryonic Induction / genetics*
Genes, Lethal / physiology
Motor Neurons / physiology*
Muscles / embryology*
Mutagenesis
Nervous System / embryology*
Neurons / physiology
Phenotype
Spinal Cord / embryology
Synapses / physiology*
Zebrafish
Grant Support
ID/Acronym/Agency:
HD22486/HD/NICHD NIH HHS; NS17963/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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