Document Detail

Genetic control over fragile X chromosome expression.
MedLine Citation:
PMID:  3698329     Owner:  NLM     Status:  MEDLINE    
The cytogenetic expression of fragile sites is highly variable. Sites are seen in differing proportions of cells. To determine if part of this variability is genetic, the proportions of lymphocytes manifesting the fragile X were examined in a large cohort of males with the fragile X chromosome. The number of fragile X cells was solely determined by genetic factors: the heritability as determined from the correlation between brothers as well as between cousins was 99.6% and 94.4%, respectively, as compared with 0% in unrelated males with the fragile X. This is consistent with pure genetic determination without any environmental influence over the expression of the fragile X chromosome in males.
F Hecht; J P Fryns; R F Vlietinck; H Van den Berghe
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical genetics     Volume:  29     ISSN:  0009-9163     ISO Abbreviation:  Clin. Genet.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-06-02     Completed Date:  1986-06-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0253664     Medline TA:  Clin Genet     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  191-5     Citation Subset:  IM    
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MeSH Terms
Cells, Cultured
Diseases in Twins
Fragile X Syndrome / genetics*,  pathology
Genetic Variation
Lymphocytes / ultrastructure
Mental Retardation / genetics
Sex Chromosome Aberrations / genetics*
Grant Support

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