Document Detail


Genetic control of novel food preference in mice.
MedLine Citation:
PMID:  15014968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In food preference studies, mammals are often categorized as being either neophilic or neophobic, i.e., preferring or disliking a novel-tasting food. To date, the genetic factors influencing novel food preference have not been elucidated. To understand this phenomenon, we investigated the genetics of food preference in eight inbred strains of mice. We gave them plain-, cinnamon-, or cocoa-flavored powdered food on day 0 for 45 min and then a choice of cinnamon- or cocoa-flavored food 14 days later. We determined their preference for novel versus already-experienced flavored food and found that some inbred strains chose the food that they had been given previously, while others chose a different food. In particular, the DBA/2 strain chose more cinnamon-flavored food after it was pre-exposed to cinnamon, while the B6 strain chose less cinnamon-flavored food after this initial exposure. The BXD recombinant inbred (RI) strain set was then used to map quantitative trait loci (QTLs) that influence this novel food preference. One of these QTLs was found to map to the distal end of Chromosome (Chr) 8.
Authors:
Valerie J Bolivar; Lorraine Flaherty
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Mammalian genome : official journal of the International Mammalian Genome Society     Volume:  15     ISSN:  0938-8990     ISO Abbreviation:  Mamm. Genome     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-11     Completed Date:  2004-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100916     Medline TA:  Mamm Genome     Country:  United States    
Other Details:
Languages:  eng     Pagination:  193-8     Citation Subset:  IM    
Affiliation:
Genomics Institute, Wadsworth Center, 465 Jordan Road, Troy, New York 12180, USA. bolivar@wadsworth.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Cacao
Chromosome Mapping
Cinnamomum zeylanicum
Food Preferences / physiology*
Mice
Mice, Inbred Strains
Quantitative Trait Loci / genetics*
Taste*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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