Document Detail

Genetic control of natural resistance of mouse macrophages to Coxiella burnetii infection in vitro: macrophages from restrictive strains control parasitophorous vacuole maturation.
MedLine Citation:
PMID:  15039367     Owner:  NLM     Status:  MEDLINE    
Macrophages from A/J and BALB/c mice were more susceptible to Coxiella burnetii phase II infection than were those from C57BL/6, C57BL/10, B10.A, C3H/HePas, and Swiss mice. Resistant macrophages effectively controlled the development of large replication vacuoles (LRVs), which accounted for the restriction of bacterial multiplication within the cultures. However, compared to fibroblasts, all macrophages controlled bacterial multiplication within LRVs.
Dario S Zamboni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Infection and immunity     Volume:  72     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-24     Completed Date:  2004-05-07     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2395-9     Citation Subset:  IM    
Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, UNIFESP, São Paulo SP 04023-062, Brazil.
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MeSH Terms
Bone Marrow Cells
Cells, Cultured
Coxiella burnetii / pathogenicity*
Immunity, Innate*
L Cells (Cell Line)
Macrophages / immunology*,  microbiology
Mice, Inbred Strains
Q Fever / genetics*,  immunology*,  microbiology,  physiopathology
Vacuoles / microbiology

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