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Genetic control of cell-mediated lympholysis in mouse.
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MedLine Citation:
PMID:  4139231     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
H-2 congenic mouse strains were tested in vitro to investigate the genetic control of cell-mediated lympholysis (CML). Combinations were selected such that differences in various segments of H-2 could be examined for their ability to stimulate production of effector cells and to serve as targets for lysis. Particular emphasis was directed towards understanding the roles of LD and SD. SD-region differences are important in the sensitization of effector cells and they also function as strong targets for lysis, or as markers for the CML targets. LD differences are also important for sensitization of cytotoxic effector cells, but they serve only as very weak targets for lysis. Collaboration occurs between LD and SD in generation of CML. The nature of this interaction can be of two types: together LD and SD can produce CML which neither difference alone can stimulate; LD can enhance a CML response stimulated by SD-region differences alone.
Authors:
D J Schendel; F H Bach
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  140     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1974 Dec 
Date Detail:
Created Date:  1975-02-18     Completed Date:  1975-02-18     Revised Date:  2010-06-22    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1534-46     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon Radioisotopes
Chromium Radioisotopes
Chromosome Mapping
Cytotoxicity Tests, Immunologic
Epitopes
Female
Genes*
Genotype
Histocompatibility Antigens*
Hot Temperature
Immunity, Cellular*
Lectins
Lymphocyte Activation
Lymphocyte Culture Test, Mixed
Lymphocytes / immunology*
Male
Mice
Mice, Inbred Strains
Phenotype
Spleen / cytology
Thymidine
Tritium
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Chromium Radioisotopes; 0/Epitopes; 0/Histocompatibility Antigens; 0/Lectins; 10028-17-8/Tritium; 50-89-5/Thymidine
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © 1974 by The Rockefeller University Press
Received Day: 29 Month: 7 Year: 1974
Print publication date: Day: 30 Month: 11 Year: 1974
Volume: 140 Issue: 6
First Page: 1534 Last Page: 1546
ID: 2139750
PubMed Id: 4139231

GENETIC CONTROL OF CELL-MEDIATED LYMPHOLYSIS IN MOUSE
Dolores J. Schendel
Fritz H. Bach
From the Departments of Medical Genetics and Surgery, and the Immunobiology Research Center, The University of Wisconsin, Madison, Wisconsin 53706


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