Document Detail


Genetic control of the CD4/CD8 T-cell ratio in humans.
MedLine Citation:
PMID:  7489409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the genetic pattern of inheritance of the ratio between circulating CD4+ and CD8+ T lymphocytes in a population of healthy donors. The distribution of the CD4/CD8 ratio in males and females was significantly different and was significantly affected by age. In 46 randomly selected families, the parental CD4/CD8 ratio significantly influenced the ratio in offspring. Complex segregation analysis of the data rejected the non-genetic hypothesis; among the genetic models tested, a major recessive gene with a polygenic component and random environmental effects was the most parsimonious model. These findings indicate that the ratio of CD4+ and CD8+ T cells is genetically controlled in humans.
Authors:
A Amadori; R Zamarchi; G De Silvestro; G Forza; G Cavatton; G A Danieli; M Clementi; L Chieco-Bianchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature medicine     Volume:  1     ISSN:  1078-8956     ISO Abbreviation:  Nat. Med.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-01-02     Completed Date:  1996-01-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9502015     Medline TA:  Nat Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1279-83     Citation Subset:  IM; X    
Affiliation:
Institute of Oncology, Interuniversity Center for Research on Cancer, University of Padova, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
CD4-CD8 Ratio*
CD4-Positive T-Lymphocytes / immunology*,  ultrastructure
CD8-Positive T-Lymphocytes / immunology*,  ultrastructure
Female
Genes, Recessive
Genetics, Population
Humans
Italy
Male
Models, Genetic
Phenotype*
Sex Factors
Comments/Corrections
Comment In:
Nat Med. 1995 Dec;1(12):1240-1   [PMID:  7489396 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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