| Genetic control of the CD4/CD8 T-cell ratio in humans. | |
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MedLine Citation:
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PMID: 7489409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the genetic pattern of inheritance of the ratio between circulating CD4+ and CD8+ T lymphocytes in a population of healthy donors. The distribution of the CD4/CD8 ratio in males and females was significantly different and was significantly affected by age. In 46 randomly selected families, the parental CD4/CD8 ratio significantly influenced the ratio in offspring. Complex segregation analysis of the data rejected the non-genetic hypothesis; among the genetic models tested, a major recessive gene with a polygenic component and random environmental effects was the most parsimonious model. These findings indicate that the ratio of CD4+ and CD8+ T cells is genetically controlled in humans. |
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Authors:
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A Amadori; R Zamarchi; G De Silvestro; G Forza; G Cavatton; G A Danieli; M Clementi; L Chieco-Bianchi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nature medicine Volume: 1 ISSN: 1078-8956 ISO Abbreviation: Nat. Med. Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1996-01-02 Completed Date: 1996-01-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9502015 Medline TA: Nat Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1279-83 Citation Subset: IM; X |
Affiliation:
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Institute of Oncology, Interuniversity Center for Research on Cancer, University of Padova, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors CD4-CD8 Ratio* CD4-Positive T-Lymphocytes / immunology*, ultrastructure CD8-Positive T-Lymphocytes / immunology*, ultrastructure Female Genes, Recessive Genetics, Population Humans Italy Male Models, Genetic Phenotype* Sex Factors |
| Comments/Corrections | |
Comment In:
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Nat Med. 1995 Dec;1(12):1240-1
[PMID:
7489396
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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