| Genetic contributions to pain: a review of findings in humans. | |
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MedLine Citation:
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PMID: 19193196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pain represents the major motivating factor for which individuals seek healthcare, and pain responses are characterized by substantial inter-individual differences. Increasing evidence suggests that genetic factors contribute significantly to individual differences in responses to both clinical and experimental pain. The purpose of this review article was to summarize the current literature regarding genetic contributions to pain, highlighting findings relevant to oral pain where available. A brief discussion of methodologic considerations is followed by a review of findings regarding genetic influences on clinical pain. Next, the literature examining genetic contributions to experimental pain responses is presented, emphasizing genetic associations that have been replicated in multiple cohorts. It is hoped that an enhanced understanding of genetic contributions to pain responses will ultimately improve diagnosis and treatment of clinical pain conditions. |
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Authors:
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R B Fillingim; M R Wallace; D M Herbstman; M Ribeiro-Dasilva; R Staud |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Oral diseases Volume: 14 ISSN: 1601-0825 ISO Abbreviation: Oral Dis Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2009-02-05 Completed Date: 2009-04-01 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9508565 Medline TA: Oral Dis Country: Denmark |
Other Details:
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Languages: eng Pagination: 673-82 Citation Subset: D |
Affiliation:
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College of Dentistry, University of Florida, Gainesville, FL 32608, USA. rfilling@ufl.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chronic Disease Facial Pain / genetics Genes Humans Pain / genetics* Pain Threshold / classification Phenotype Twin Studies as Topic Twins / genetics |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR000082-467225/RR/NCRR NIH HHS; NS41670/NS/NINDS NIH HHS; R01 NS041670-08/NS/NINDS NIH HHS; RR00082/RR/NCRR NIH HHS |
| Comments/Corrections | |
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