Document Detail

Genetic contributions to labor pain and progress.
MedLine Citation:
PMID:  23972758     Owner:  NLM     Status:  In-Data-Review    
Studies on genetic contributions to labor analgesia have essentially evaluated the μ-opioid receptor gene (OPRM1), with some evidence that p.118A/G of OPRM1 influences the response to neuraxial opioids. As for labor progress, the β2-adrenergic receptor gene (ADRB2) is associated with preterm labor and delivery, and impacts the course of labor. Taken together though, there is no evidence that pharmacogenetic testing is needed or beneficial in the context of obstetric anesthesia; however, realizing the influence of genetic variants on specific phenotypes provides the rationale for a more cautious interpretation of clinical studies that attempt to find a dose-regimen that fits all.
Ruth Landau
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Publication Detail:
Type:  Journal Article     Date:  2013-06-27
Journal Detail:
Title:  Clinics in perinatology     Volume:  40     ISSN:  1557-9840     ISO Abbreviation:  Clin Perinatol     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  575-87     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Department of Anesthesiology and Pain Medicine, University of Washington Medical Center, 1959 NE Pacific Street, Suite BB 1415B, Seattle, WA 98195-6540, USA. Electronic address:
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