| Genetic contribution to DZ twinning. | |
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MedLine Citation:
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PMID: 8741868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The genetic contribution to dizygotic (DZ) twinning was investigated using 6,596 twin pairs from the Australian Twin Registry who provided information on other twins in their families. Responses were classified by the zygosity (DZ; monozygotic [MZ]) of the proband twins and by the relationship and zygosity of related twins. MZ probands and MZ twins reported by DZ probands were used as controls and assumed to be independent of any genetic influence. Significantly higher proportions of DZ twins were found in the families of DZ probands compared to the families of MZ probands for the following relationships: sibs of probands, proband mothers, offspring of sisters of proband mothers, and offspring of female probands (P < 0.001 in each case). The latter 2 relationships were used to estimate risk ratios of 1.7 for sisters of mothers of DZ twins, and 2.5 for offspring of female DZ twins. No greater tendency to DZ twinning in close relatives was found in mothers who bore DZ twins at a younger age than at an older age. |
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Authors:
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C M Lewis; S C Healey; N G Martin |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Twin Study |
Journal Detail:
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Title: American journal of medical genetics Volume: 61 ISSN: 0148-7299 ISO Abbreviation: Am. J. Med. Genet. Publication Date: 1996 Jan |
Date Detail:
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Created Date: 1996-10-21 Completed Date: 1996-10-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7708900 Medline TA: Am J Med Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 237-46 Citation Subset: IM |
Affiliation:
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Department of Medical Informatics, University of Utah, Salt Lake City, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Australia Female Humans Male Maternal Age Odds Ratio Pedigree Registries Twins, Dizygotic / genetics* Twins, Monozygotic / genetics |
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