Document Detail


Genetic contribution to DZ twinning.
MedLine Citation:
PMID:  8741868     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The genetic contribution to dizygotic (DZ) twinning was investigated using 6,596 twin pairs from the Australian Twin Registry who provided information on other twins in their families. Responses were classified by the zygosity (DZ; monozygotic [MZ]) of the proband twins and by the relationship and zygosity of related twins. MZ probands and MZ twins reported by DZ probands were used as controls and assumed to be independent of any genetic influence. Significantly higher proportions of DZ twins were found in the families of DZ probands compared to the families of MZ probands for the following relationships: sibs of probands, proband mothers, offspring of sisters of proband mothers, and offspring of female probands (P < 0.001 in each case). The latter 2 relationships were used to estimate risk ratios of 1.7 for sisters of mothers of DZ twins, and 2.5 for offspring of female DZ twins. No greater tendency to DZ twinning in close relatives was found in mothers who bore DZ twins at a younger age than at an older age.
Authors:
C M Lewis; S C Healey; N G Martin
Related Documents :
16258338 - Should we deliver twins electively at 37 weeks' gestation?
2520788 - Breech extraction versus cesarean section for the remaining second twin.
19060578 - Differences in short-term neonatal outcomes between discordant twins.
1053248 - The inheritance of scholastric abilities in a sample of twins. i. ascertainments of the...
24749088 - Neonatal late-onset hypocalcemia: is there any relationship with maternal hypovitaminos...
10571948 - Compound sftpb 1549c-->gaa (121ins2) and 457delc heterozygosity in severe congenital lu...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Twin Study    
Journal Detail:
Title:  American journal of medical genetics     Volume:  61     ISSN:  0148-7299     ISO Abbreviation:  Am. J. Med. Genet.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-10-21     Completed Date:  1996-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708900     Medline TA:  Am J Med Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  237-46     Citation Subset:  IM    
Affiliation:
Department of Medical Informatics, University of Utah, Salt Lake City, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Australia
Female
Humans
Male
Maternal Age
Odds Ratio
Pedigree
Registries
Twins, Dizygotic / genetics*
Twins, Monozygotic / genetics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Correlations of placental vascular anatomy and clinical outcomes in 69 monochorionic twin pregnancie...
Next Document:  Zygosity and placental anatomy in 15 consecutive sets of spontaneously conceived triplets.