Document Detail

Genetic contribution of the CD14 -159C/T dimorphism in the promoter region in Japanese RA.
MedLine Citation:
PMID:  18565258     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the contribution of the CD14 gene to the pathogenesis of rheumatoid arthritis (RA) in Japanese patients. METHODS: CD14 genotyping was carried out at the -159C/T dimorphic site in 97 RA patients and 104 normal subjects by the PCR-RFLP (restriction fragment length polymorphism) METHOD: HLA-DRB1 genotyping was performed by the PCR-SSCP (sequence specific conformational polymorphism) method. RESULTS: The -159C/T dimorphism is not associated with whole RA or with female RA, and the results were compatible with a previous report from Germany. The -159C/T dimorphism was not associated with rheumatoid factor (RF)-positive RA, although the -159T allele tended to be associated with RF in the German report. The -159C/T dimorphism showed no association even in RA patients with the RA-susceptibility HLA-DRB1*0405. The -159T allele was prevalent in Japanese controls. CONCLUSION: The CD14 gene is very unlikely to be genetically involved in the pathogenesis of Japanese RA.
F Takeuchi; N Nakaue; N Kobayashi; S Kuwata; T Murayama; K Kawasugi; M Mori; K Matsuta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  26     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2008 Mar-Apr
Date Detail:
Created Date:  2008-06-20     Completed Date:  2008-07-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  337-9     Citation Subset:  IM    
Department of Internal Medicine (Allergy and Rheumatology), Faculty of Medicine, University of Tokyo, Tokyo, Japan.
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MeSH Terms
Antigens, CD14 / genetics*
Arthritis, Rheumatoid / ethnology*,  genetics*
Genetic Predisposition to Disease / ethnology
Japan / epidemiology
Middle Aged
Polymorphism, Restriction Fragment Length
Polymorphism, Single-Stranded Conformational
Promoter Regions, Genetic / genetics
Reg. No./Substance:
0/Antigens, CD14

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