Document Detail


Genetic characterization of hantaviruses transmitted by the Korean field mouse (Apodemus peninsulae), Far East Russia.
MedLine Citation:
PMID:  12141960     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In an epizootiologic survey of 122 rodents captured in Vladivostok, Russia, antibodies positive for hantavirus were found in Apodemus peninsulae (4/70), A. agrarius (1/39), and Clethrionomys rufocanus (1/8). The hantavirus sequences identified in two seropositive A. peninsulae and two patients with hemorrhagic fever with renal syndrome (HFRS) from the Primorye region of Far East Russia were designated as Solovey and Primorye, respectively. The nucleotide sequences of the Solovey, Primorye, and Amur (obtained through GenBank) sequences were closely related (>92% identity). Solovey and Primorye sequences shared 84% nucleotide identity with the prototype Hantaan 76-118. Phylogenetic analysis also indicated a close relationship between Solovey, Primorye, Amur, and other viruses identified in Russia, China, and Korea. Our findings suggest that the Korean field mouse (A. peninsulae) is the reservoir for a hantavirus that causes HFRS over a vast area of east Asia, including Far East Russia.
Authors:
Kumari Lokugamage; Hiroaki Kariwa; Daisuke Hayasaka; Bai Zhong Cui; Takuya Iwasaki; Nandadeva Lokugamage; Leonid I Ivanov; Vladimir I Volkov; Vladimir A Demenev; Raisa Slonova; Galina Kompanets; Tatyana Kushnaryova; Takeshi Kurata; Kenji Maeda; Koichi Araki; Tetsuya Mizutani; Kumiko Yoshimatsu; Jiro Arikawa; Ikuo Takashima
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Emerging infectious diseases     Volume:  8     ISSN:  1080-6040     ISO Abbreviation:  Emerging Infect. Dis.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-26     Completed Date:  2002-09-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9508155     Medline TA:  Emerg Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  768-76     Citation Subset:  IM    
Affiliation:
Hokkaido University, Sapporo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Viral / blood
Base Sequence
Carrier State / transmission,  veterinary,  virology
DNA, Viral / genetics
Genetic Variation
Hantavirus / classification,  genetics*,  isolation & purification*
Hantavirus Infections / transmission,  veterinary*,  virology*
Humans
Mice / virology*
Molecular Sequence Data
Phylogeny
RNA, Viral / genetics
Reverse Transcriptase Polymerase Chain Reaction
Russia
Sequence Homology, Nucleic Acid
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/DNA, Viral; 0/RNA, Viral
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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