| Genetic characterization of enterovirus 71 isolated from patients with severe disease by comparative analysis of complete genomes. | |
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MedLine Citation:
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PMID: 22499017 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Enterovirus 71 (EV71) which causes mild illness in children is also associated with severe neurological complications. This study analyzed the complete genomes of EV71 strains derived from mild and severe diseases in order to determine whether the differences of EV71 genomes were responsible for different clinical presentations. Compared to complete genomes of EV71 strains derived from mild cases (less virulent strains), nucleotide differences in EV71 strains isolated from severe cases (more virulent strains) were observed primarily in the internal ribosomal entry site (IRES) of the 5'-untranslated region (UTR), which is vital for the cap-independent translation of viral proteins. In the protein-coding region, an E-Q substitution at amino acid position 145 of structural protein VP1 that occurred in more than one of more virulent strains was observed. This site is known to be related functionally to receptor binding and virulence in mice. Overall, strains (Group III) isolated from patients with fatal or severe sequelae outcomes had greater sequence substitutions in the 5'-UTR and/or protein-coding region and exhibited a relatively low-average homology to less virulent strains across the entire genome, indicating the possibility of significant genomic diversity in the most virulent EV71 strains. Further studies of EV71 pathogenesis should examine the significance of genomic diversity and the effects of multiple mutations in a viral population. J. Med. Virol. 84:931-939, 2012. © 2012 Wiley Periodicals, Inc. |
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Authors:
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Shih-Cheng Chang; Wen-Chen Li; Guang-Wu Chen; Kuo-Chien Tsao; Chung-Guei Huang; Yhu-Chering Huang; Cheng-Hsun Chiu; Chen-Yen Kuo; Kun-Nan Tsai; Shin-Ru Shih; Tzou-Yien Lin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medical virology Volume: 84 ISSN: 1096-9071 ISO Abbreviation: J. Med. Virol. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-04-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7705876 Medline TA: J Med Virol Country: United States |
Other Details:
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Languages: eng Pagination: 931-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Research Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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