| Genetic characterization of HIV-1 from semen and blood from clade C-infected subjects from India and effect of therapy in these body compartments. | |
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MedLine Citation:
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PMID: 20231027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Biologic and genetic differences between HIV-1 clade C in India and clade B in US suggest that the effect of anti-viral therapy in various body compartments may differ between these two clades. We examined the effect of therapy on viral loads in semen and blood of HIV-1-clade C infected subjects from India and evaluated whether HIV-1 in the semen is different from that in blood in these subjects. HIV-1 RNA was detected in semen and blood at all stages of the disease. Viral loads in semen and blood were strongly correlated with each other, but not with the CD4+ T cell count. Anti-viral treatment reduced viral load drastically in blood and semen within one month of post therapy. Genetic characterization of HIV-1 in the semen and blood demonstrated that they were highly compartmentalized. These data have important implications of sexual transmission of HIV-1 in clade C HIV-1 infected subjects. |
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Authors:
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Chengli Shen; Ming Ding; Jodi K Craigo; Patrick Tarwater; Ramdas Chatterjee; Pratima Roy; Subhasish K Guha; Bibhuti Saha; Dolonchapa Modak; Dhrubak Neogi; Yue Chen; Phalguni Gupta |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-03-15 |
Journal Detail:
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Title: Virology Volume: 401 ISSN: 1096-0341 ISO Abbreviation: Virology Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-30 Completed Date: 2010-05-10 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0110674 Medline TA: Virology Country: United States |
Other Details:
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Languages: eng Pagination: 190-6 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-HIV Agents / therapeutic use* Blood / virology* CD4 Lymphocyte Count HIV Infections / drug therapy, virology* HIV-1 / classification*, genetics*, isolation & purification Humans India Male Middle Aged Molecular Sequence Data Polymorphism, Genetic RNA, Viral / genetics, isolation & purification Semen / virology* Sequence Analysis, DNA Viral Load* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R21 AI065392-01A1/AI/NIAID NIH HHS; R21AI65392/AI/NIAID NIH HHS; TW001038-06/TW/FIC NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/RNA, Viral |
| Comments/Corrections | |
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