| Genetic causes of human heart failure. | |
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MedLine Citation:
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PMID: 15765133 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Factors that render patients with cardiovascular disease at high risk for heart failure remain incompletely defined. Recent insights into molecular genetic causes of myocardial diseases have highlighted the importance of single-gene defects in the pathogenesis of heart failure. Through analyses of the mechanisms by which a mutation selectively perturbs one component of cardiac physiology and triggers cell and molecular responses, studies of human gene mutations provide a window into the complex processes of cardiac remodeling and heart failure. Knowledge gleaned from these studies shows promise for defining novel therapeutic targets for genetic and acquired causes of heart failure. |
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Authors:
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Hiroyuki Morita; Jonathan Seidman; Christine E Seidman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 115 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-14 Completed Date: 2005-05-09 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 518-26 Citation Subset: AIM; IM |
Affiliation:
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Department of Genetics, Harvard Medical School, Division of Cardiology, Brigham and Women's Hospital, and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism Cardiac Output, Low / genetics*, physiopathology Cardiovascular Diseases / genetics Cardiovascular Physiological Phenomena Energy Metabolism / genetics Gene Expression Regulation Humans Mitochondria / genetics, metabolism Muscle Proteins / genetics, metabolism Mutation* Myocardium / cytology, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Muscle Proteins; 7440-70-2/Calcium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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