Document Detail


Genetic biomarkers in Brugada syndrome.
MedLine Citation:
PMID:  23905889     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Brugada syndrome is an inherited arrhythmia syndrome predisposing to sudden cardiac death. Six years after its initial description as a clinical entity, the first mutations in SCN5A encoding the cardiac sodium channel Nav1.5 were reported. Over 300 mutations in SCN5A have since been described in addition to mutations in genes encoding Nav1.5 auxiliary units, potassium and calcium channels. This review summarizes the current knowledge on the genetics of Brugada syndrome, focusing on SCN5A, and discusses its use as a biomarker for diagnosis, prognosis and treatment.
Authors:
Anthony Li; Magdi M Saba; Elijah R Behr
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomarkers in medicine     Volume:  7     ISSN:  1752-0371     ISO Abbreviation:  Biomark Med     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-08-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101312535     Medline TA:  Biomark Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  535-46     Citation Subset:  IM    
Affiliation:
Cardiovascular Sciences Research Centre, St George's University of London, Cranmer Terrace, London, SW17 0RE, UK.
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