| Genetic basis of malignant channelopathies and ventricular fibrillation in the structurally normal heart. | |
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MedLine Citation:
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PMID: 20462344 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sudden cardiac death occurs in a minority of patients in the absence of structural or functional abnormalities. In this category, pure electrical heart diseases are responsible for a large number of these unexpected deaths. These conditions include the long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, short QT syndrome (collectively referred to as channelopathies) and idiopathic ventricular fibrillation. This article reviews the current molecular understanding of the electrical diseases of the heart associated with sudden cardiac death, and provides a summary of the causal genes and a flowchart with an overview of the genotype-phenotype correlation of the most common arrhythmia syndromes. |
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Authors:
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Nynke Hofman; Laura T van Lochem; Arthur A M Wilde |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Future cardiology Volume: 6 ISSN: 1744-8298 ISO Abbreviation: Future Cardiol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-13 Completed Date: 2010-08-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101239345 Medline TA: Future Cardiol Country: England |
Other Details:
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Languages: eng Pagination: 395-408 Citation Subset: IM |
Affiliation:
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Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arrhythmias, Cardiac
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genetics* Calcium Signaling / genetics Catecholamines / genetics Electrocardiography Epilepsy / complications, genetics Gastrointestinal Diseases / genetics Heart Conduction System Humans Ion Channels / genetics* Mutation |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Ion Channels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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