| Genetic basis of inter-individual variability in the effects of exercise on the alleviation of lifestyle-related diseases. | |
| | |
MedLine Citation:
|
PMID: 19736300 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Habitual exercise training, including a high-intensity interval walking programme, improves cardiorespiratory fitness and alleviates lifestyle-related diseases, such as obesity, hypertension and dyslipidaemia. However, the extent of improvement has been shown to differ substantially among individuals for various exercise regimens. A body of literature has demonstrated that gene polymorphisms could account for the inter-individual variability in the improvement of risk factors for lifestyle-related diseases following exercise training. However, the fractions of the variability explained by the polymorphisms are small (5%). Also, it is likely that the effects of gene polymorphisms differ with exercise regimens and subject characteristics. These observations suggest the necessity for further studies to exhaustively identify such gene polymorphisms. More importantly, the physiological and molecular genetic mechanisms by which gene polymorphisms interact with exercise to influence the improvements of risk factors for lifestyle-related diseases differentially remain to be clarified. A better understanding of these issues should lead to more effective integration of exercise to optimize the treatment and management of individuals with lifestyle-related diseases. |
| | |
Authors:
|
Masayuki Mori; Keiichi Higuchi; Akihiro Sakurai; Yasuharu Tabara; Tetsuro Miki; Hiroshi Nose |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-09-07 |
Journal Detail:
|
Title: The Journal of physiology Volume: 587 ISSN: 1469-7793 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-12-04 Completed Date: 2010-02-17 Revised Date: 2011-03-03 |
Medline Journal Info:
|
Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
|
Languages: eng Pagination: 5577-84 Citation Subset: IM |
Affiliation:
|
Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan. masamori@shinshu-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Dyslipidemias
/
prevention & control Exercise / physiology* Genetics* Genotype Humans Hypertension / prevention & control Life Style* Obesity / prevention & control Oxygen Consumption Physical Fitness / physiology* Polymorphism, Genetic Walking / physiology |
| Comments/Corrections | |
Comment In:
|
J Physiol. 2010 Mar 15;588(Pt 6):1023-4; author reply 1025
[PMID:
20231148
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Differential expression of membrane conductances underlies spontaneous event initiation by rostral m...
Next Document: Nerve-evoked purinergic signalling suppresses action potentials, Ca2+ flashes and contractility evok...