Document Detail


Genetic associations between myasthenia gravis and the HL-A system.
MedLine Citation:
PMID:  1255208     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HL-A antigens were determined in 159 myasthenic patients, 112 of whom were females and 47 males. Fifty-seven patients were thymectomized. The relationship between 23 different HL-A antigens and myasthenia gravis (MG) with reference to sex, age at onset, clinical course of MG, thymus histology, and auxiliary diseases of the patients, as well as the significance of these antigens to 245 relatives of myasthenics, were analysed. The frequencies of HL-A1 and HL-A8 were highly significantly higher in myasthenic patients than in normal Finnish controls. The increase of HL-A1 is secondary and due to a strong linkage disequilibrium between HL-A8 and HL-A1. HL-A8 appeared most often in females with onset of MG before the age of 35 years, and inpatients with thymus hyperplasia. No significant HL-A deviations were found in males or in females with later onset of disease. In seven thymoma patients the occurrence of W10 antigen was almost significantly increased.
Authors:
R Pirskanen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  39     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1976 Jan 
Date Detail:
Created Date:  1976-06-02     Completed Date:  1976-06-02     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  23-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Autoimmune Diseases / complications
Female
HLA Antigens*
Histocompatibility Antigens*
Male
Myasthenia Gravis / complications,  genetics*,  immunology
Phenotype
Sex Factors
Thymoma / complications
Thymus Hyperplasia / complications
Thymus Neoplasms / complications
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/Histocompatibility Antigens
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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