Document Detail


Genetic association study of tumor necrosis factor-alpha with sepsis and septic shock in Thai pediatric patients.
MedLine Citation:
PMID:  23033000     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To evaluate the association between the genetic polymorphism of the tumor necrosis factor-alpha (TNF-α) gene and the development of sepsis and septic shock in Thai pediatric patients and to investigate the clinical impacts of TNF-α polymorphisms in this population.
METHODS: To perform this genetic association study, a prospective analysis of pediatric patients (age < 18 years) with clinical sepsis/septic shock was conducted. All clinical data were collected by pediatric intensive care experts, and genetic analyses were performed at a central laboratory. A single nucleotide polymorphism (SNP) located in the 5'-promoter region at position -308 was genotyped and the results were associated with clinical phenotypes.
RESULTS: A total of 167 Thai individuals were investigated, 66 of which were pediatric patients with sepsis/septic shock and 101 were healthy controls. Interestingly, we could not identify an association between sepsis and -308 (G/A) polymorphism, which have previously been demonstrated to be a major SNP associated with sepsis in several Caucasian populations, since there was no frequency difference between cases and controls.
CONCLUSIONS: In this report, the major TNF-α polymorphism (-308) was not associated with clinical sepsis/septic shock in Thais. This information will be important for future analyses to identify the role of TNF-α as a genetic risk for the development of immunopathology underlying several diseases in Asia.
Authors:
Suwannee Phumeetham; Nunthawut Chat-Uthai; Manutham Manavathongchai; Vip Viprakasit
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-02
Journal Detail:
Title:  Jornal de pediatria     Volume:  88     ISSN:  1678-4782     ISO Abbreviation:  J Pediatr (Rio J)     Publication Date:    2012 Sep-Oct
Date Detail:
Created Date:  2012-10-24     Completed Date:  2013-05-07     Revised Date:  2013-06-29    
Medline Journal Info:
Nlm Unique ID:  2985188R     Medline TA:  J Pediatr (Rio J)     Country:  Brazil    
Other Details:
Languages:  eng; por     Pagination:  417-22     Citation Subset:  IM    
Affiliation:
Mahidol University, Bangkok, Thailand.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Asian Continental Ancestry Group / genetics
Child
Child, Preschool
Epidemiologic Methods
Gene Frequency
Genotype
Humans
Infant
Infant, Newborn
Male
Polymorphism, Genetic / genetics*
Sepsis / genetics*,  mortality
Shock, Septic / genetics*,  mortality
Thailand / epidemiology
Tumor Necrosis Factor-alpha / genetics*
Chemical
Reg. No./Substance:
0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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