| Genetic association of cytokines polymorphisms with autoimmune hepatitis and primary biliary cirrhosis in the Chinese. | |
| | |
MedLine Citation:
|
PMID: 15884119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: To characterize gene polymorphism of several cytokine gene in-patients with AIH and PBC and to analyze the difference of the polymorphism distribution between Chinese patients and healthy controls. METHODS: The study population consisted of 62 patients with AIH, and 77 patients with PBC. The genetic profile of four cytokines was analyzed by restriction fragment length polymorphism after specific PCR amplification (PCR-RFLP) or sequence-specific primers PCR (SSP-PCR). The analyzed gene polymorphism included interleukin-1 (IL-1) (at position +3 953 and IL-1RN intron 2), IL-6 (at position -174), IL-10 promoter (at position -1 082, -819, and -592). The control group consisted of 160 healthy blood donors. RESULTS: The majority of Chinese people including patients and healthy controls exhibited IL-1B 1,1 genotype, and there was no significant difference in AIH, PBC patients and controls. There were highly statistically significant differences in the distribution of the IL-1RN gene polymorphism between the patients with PBC compared with controls. The frequency of IL-1RN 1,1 was significantly higher (90.9% vs 79.4%, P = 0.03) and the frequency of IL-1RN 1,2 was significantly lower in PBC patients (6.5% vs 17.5%, P = 0.01). No statistical difference was observed between AIH patients and controls. All of the 160 healthy controls and 62 cases of AIH patients exhibited IL-6-174GG genotype, and there were four cases, which expressed IL-6-174GC genotype in 77 cases of PBC patients. The frequency of IL-6-174GC was markedly significantly higher in PBC patients compared with controls (5.2% vs 0%, P = 0.004). No statistically significant difference was found in the distribution of IL-10 promoter genotype in AIH and PBC patients compared with controls. CONCLUSION: The polymorphisms of IL-1RN and IL-6 -174G/C appear to be associated with PBC in Chinese patients. |
| | |
Authors:
|
Lie-Ying Fan; Xiao-Qing Tu; Ye Zhu; Thomas Pfeiffer; Ralph Feltens; Winfried Stoecker; Ren-Qian Zhong |
Related Documents
:
|
10326109 - Ultrasonography of the liver and spleen in brazilian patients with hepatosplenic schist... 21264789 - Serum folate and homocysteine levels are associated with colon tumorigenesis in end-sta... 6316569 - Alpha-1-antitrypsin deficiency and hepatocellular carcinoma. determination of pi phenot... 15259509 - Hypercoagulable states in patients with hepatocellular carcinoma. 19568519 - Prevalence and factors affecting occurrence of type 2 diabetes mellitus in saudi patien... 20495469 - Nitric oxide, ammonia, and crp levels in cirrhotic patients with hepatic encephalopathy... 7330849 - Hla and alopecia areata in jerusalem. 10852689 - The safety of intravenous iron dextran (dexferrum) during hemodialysis in patients with... 20404959 - Safety and efficacy of pedicle screws and titanium mesh cage in the treatments of tuber... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: World journal of gastroenterology : WJG Volume: 11 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2005 May |
Date Detail:
|
Created Date: 2005-05-10 Completed Date: 2005-07-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
|
Languages: eng Pagination: 2768-72 Citation Subset: IM |
Affiliation:
|
The Department of Medicine Laboratory, East Hospital, Ji Mo Road 150, Shanghai 200120, China. flieying@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Asian Continental Ancestry Group / genetics* Cytokines / genetics* Female Hepatitis, Autoimmune / genetics* Humans Liver Cirrhosis, Biliary / genetics* Male Middle Aged Polymorphism, Genetic* |
| Chemical | |
Reg. No./Substance:
|
0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Helicobacter pylori eradication lowers serum homocysteine level in patients without gastric atrophy.
Next Document: Assessment of small intestinal bacterial overgrowth in uncomplicated acute diverticulitis of the col...