Document Detail


Genetic association between RGS1 and internalizing disorders.
MedLine Citation:
PMID:  23324853     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Quantitative trait loci identified in animal models provide potential candidate susceptibility loci for human disorders. In this study, we investigated whether internalizing disorders (anxiety disorders, major depression, and neuroticism) were associated with a region on human chromosome 1 syntenic with a quantitative trait locus for rodent emotionality.
METHODS: We genotyped 31 single-nucleotide polymorphisms in genes located on chromosome 1q31.2 in a two-stage association study of 1128 individuals chosen for a high or a low genetic risk for internalizing disorders from the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders.
RESULTS: None of the individual single-nucleotide polymorphisms showed consistent association across stages. A four-marker haplotype in the regulator of G-protein signaling 1 gene (RGS1) was significantly associated with decreased internalizing risk in both stages, whereas another showed a nominal association with a higher risk.
CONCLUSION: Our data suggest that markers in the RGS1 gene might be in linkage disequilibrium with a protective allele that reduces the risk of anxiety and depressive disorders.
Authors:
John M Hettema; Seon-Sook An; Edwin J C G van den Oord; Michael C Neale; Kenneth S Kendler; Xiangning Chen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Psychiatric genetics     Volume:  23     ISSN:  1473-5873     ISO Abbreviation:  Psychiatr. Genet.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-02-25     Completed Date:  2013-10-22     Revised Date:  2014-06-27    
Medline Journal Info:
Nlm Unique ID:  9106748     Medline TA:  Psychiatr Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  56-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Genetic Association Studies*
Genetic Markers
Genetic Predisposition to Disease*
Haplotypes / genetics
Humans
Linkage Disequilibrium / genetics
Neurotic Disorders / genetics*
Polymorphism, Single Nucleotide / genetics
RGS Proteins / genetics*
Grant Support
ID/Acronym/Agency:
DA-11287/DA/NIDA NIH HHS; K08 MH-66277/MH/NIMH NIH HHS; K08 MH066277/MH/NIMH NIH HHS; MH-20030/MH/NIMH NIH HHS; MH-40828/MH/NIMH NIH HHS; MH-65322/MH/NIMH NIH HHS; MH/AA/DA-49492/AA/NIAAA NIH HHS; R01 DA011287/DA/NIDA NIH HHS; R01 MH049492/MH/NIMH NIH HHS; UL1RR031990/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers; 0/RGS Proteins; 0/RGS1 protein, human
Comments/Corrections

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