| Genetic association of Glutathione peroxidase-1 (GPx-1) and NAD(P)H:Quinone Oxidoreductase 1(NQO1) variants and their association of CAD in patients with type-2 diabetes. | |
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MedLine Citation:
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PMID: 21989715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Coronary artery disease (CAD) is a major health concern and the leading cause of death in individuals with type-2 diabetes mellitus (T2DM). Glutathione peroxidase-1 (GPx-1) and NAD(P)H: quinone oxidoreductase (NQO1) are known for its broad range of detoxification. The role of functional variants of these genes in the development of various disorders is proven. Hereby, we investigated the possible role of these variants in the development of CAD in T2DM patients of South Indian population. In this case-control study, a total of 539 patients (T2DM = 241; T2DM-CAD = 298) and 285 controls were included. The C198T GPx-1 and C609T NQO1 single-nucleotide polymorphisms were analyzed by PCR-RFLP. Further, these genotypes were correlated with blood lipid profile. Regression analysis showed that GPx1-C/T genotype is associated with a 1.35-fold increase (95% CI = 1.000-1.824; P = 0.048) and GPx1-T/T genotype is associated with a 1.76-fold increase (95% CI = 1.011 to 3.066; P = 0.046) to the T2DM development. Increased odds ratio showed that NQO1-T/T genotype had a higher occurrence of CAD in diabetic patients with CAD (95% CI = 1.003-2.674, P = 0.049) than T2DM patients without CAD. The level of triglycerides alone showed significant increase for GPx-1-C/T and -T/T genotypes in Tukey's Post hoc analysis (177.1 ± 19.2 vs. 184 ± 23.5; P = 0.039 and 177.1 ± 19.2 vs. 190 ± 22.4; P = 0.006) among the patients with T2DM-CAD. Our work concludes that GPx-1 variants might contribute to the development of diabetes and both GPx-1 and NQO1 variants confirm the association of CAD in people with T2DM of South Indian population. |
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Authors:
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Tharmarajan Ramprasath; Ponniah Senthil Murugan; Ellappan Kalaiarasan; Pannerselvam Gomathi; Andiappan Rathinavel; Govindan Sadasivam Selvam |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-10-12 |
Journal Detail:
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Title: Molecular and cellular biochemistry Volume: 361 ISSN: 1573-4919 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2011-12-28 Completed Date: 2012-04-27 Revised Date: 2012-05-28 |
Medline Journal Info:
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Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 143-50 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Center for Excellence in Genomic Sciences, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamilnadu, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amplified Fragment Length Polymorphism Analysis Case-Control Studies Coronary Artery Disease / blood, enzymology*, etiology, genetics Diabetes Mellitus, Type 2 / blood, complications, enzymology*, genetics Diabetic Angiopathies / blood, enzymology*, etiology, genetics Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Genotype Glutathione Peroxidase / genetics*, metabolism Humans India Lipids / blood Male Middle Aged NAD(P)H Dehydrogenase (Quinone) / genetics*, metabolism Odds Ratio Polymorphism, Single Nucleotide |
| Chemical | |
Reg. No./Substance:
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0/Lipids; EC 1.11.1.-/glutathione peroxidase GPX1; EC 1.11.1.9/Glutathione Peroxidase; EC 1.6.5.2/NAD(P)H Dehydrogenase (Quinone); EC 1.6.5.2/NQO1 protein, human |
| Comments/Corrections | |
Comment In:
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Pharmacogenomics. 2012 Feb;13(3):261-4
[PMID:
22304578
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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