Document Detail

Genetic aspects of idiopathic epilepsy in Labrador retrievers.
MedLine Citation:
PMID:  9673903     Owner:  NLM     Status:  MEDLINE    
A study was undertaken to define the mode of inheritance of idiopathic epilepsy in Labrador retrievers in Switzerland. Seven hundred and ninety-two pedigree certificates from a population of healthy and epileptic dogs from 11 generations were evaluated. Forty-four different families (giving a total of 55 epileptic dogs) were included. Most patients showed generalised grand mal seizures and the onset was within one to three years in 41 per cent. Males were no more affected than females and the gender ratio between epileptic and control animals was not significantly different (P > 0.05). Additionally, there was no difference in average total inbreeding coefficient between both sexes, or with respect to age of onset of seizures. The increased manifestation of seizures in some subpopulations and the repeated occurrence in different families of the same sires suggested that there was a genetic basis for the condition in the breed. Results of pedigree analyses and from use of the binomial test support the hypothesis of a polygenic, recessive mode of inheritance. However, only an objective test-mating programme is likely to define the exact mode of inheritance.
A Jaggy; D Faissler; C Gaillard; P Srenk; H Graber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of small animal practice     Volume:  39     ISSN:  0022-4510     ISO Abbreviation:  J Small Anim Pract     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-09-25     Completed Date:  1998-09-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0165053     Medline TA:  J Small Anim Pract     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  275-80     Citation Subset:  IM    
Institute of Animal Neurology, Brno, Switzerland.
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MeSH Terms
Dog Diseases / genetics*
Epilepsy / genetics,  veterinary*
Multigene Family
Polymorphism, Genetic
Comment In:
J Small Anim Pract. 1999 Apr;40(4):192   [PMID:  10340251 ]

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