| Genetic aspects of adrenocortical tumours. | |
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MedLine Citation:
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PMID: 22471738 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Adrenocortical tumours. (ACT), which include adenomas, carcinomas and adrenal hyperplasia, may be associated with genetic syndromes, such as Li-Fraumeni syndrome, Beckwith-Wiedemann syndrome, multiple endocrine neoplasia type 1, familial adenomatous polyposis and Carney complex. Genetic defects have been found to be responsible for the disease in most of these syndromes, allowing genetic counselling to affected patients and family members. Here, we summarize the clinical criteria of these hereditary syndromes and briefly describe the genetic alterations related to them. In addition, we discuss the involvement of various genetic defects in the development of sporadic adrenocortical tumours. © 2012 Blackwell Publishing Ltd. |
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Authors:
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Tânia L Mazzuco; Julien Durand; Audrey Chapman; Jefferson Crespigio; Isabelle Bourdeau |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-4 |
Journal Detail:
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Title: Clinical endocrinology Volume: - ISSN: 1365-2265 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Blackwell Publishing Ltd. |
Affiliation:
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Division of Endocrinology, Department of Medicine, Health Sciences Centre, Universidade Estadual de Londrina (UEL), Londrina, Paraná, Brazil; Division of Endocrinology, Department of Medicine, Research Centre, Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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