| Genetic architecture of voluntary exercise in an advanced intercross line of mice. | |
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MedLine Citation:
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PMID: 20388837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exercise is essential for health, yet the amount, duration, and intensity that individuals engage in are strikingly variable, even under prescription. Our focus was to identify the locations and effects of quantitative trait loci (QTL) controlling genetic predisposition for exercise-related traits, utilizing a large advanced intercross line (AIL) of mice. This AIL (G(4)) population originated from a reciprocal cross between mice with genetic propensity for increased voluntary exercise [high-runner (HR) line, selectively bred for increased wheel running] and the inbred strain C57BL/6J. After adjusting for family structure, we detected 32 significant and 13 suggestive QTL representing both daily running traits (distance, duration, average speed, and maximum speed) and the mean of these traits on days 5 and 6 (the selection criteria for HR) of a 6-day test conducted at 8 wk of age, with many co-localizing to similar genomic regions. Additionally, seven significant and five suggestive QTL were observed for the slope and intercept of a linear regression across all 6 days of running, some representing a combination of the daily traits. We also observed two significant and two suggestive QTL for body mass before exercise. These results, from a well-defined animal model, reinforce a genetic basis for the predisposition to engage in voluntary exercise, dissect this predisposition into daily segments across a continuous time period, and present unique QTL that may provide insight into the initiation, continuation, and temporal pattern of voluntary activity in mammals. |
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Authors:
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Scott A Kelly; Derrick L Nehrenberg; Jeremy L Peirce; Kunjie Hua; Brian M Steffy; Tim Wiltshire; Fernando Pardo-Manuel de Villena; Theodore Garland; Daniel Pomp |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-04-13 |
Journal Detail:
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Title: Physiological genomics Volume: 42 ISSN: 1531-2267 ISO Abbreviation: Physiol. Genomics Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-10-28 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 9815683 Medline TA: Physiol Genomics Country: United States |
Other Details:
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Languages: eng Pagination: 190-200 Citation Subset: IM |
Affiliation:
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Department of Genetics, University of North Carolina at Chapel Hill, 120 Mason Farm Rd., Chapel Hill, NC 27599-7264, USA. scottkelly@unc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromosome Mapping Crosses, Genetic Genotype Mice Mice, Inbred C57BL Models, Animal Motor Activity / genetics Physical Conditioning, Animal* Quantitative Trait Loci |
| Grant Support | |
ID/Acronym/Agency:
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5T32 MH 075854-04/MH/NIMH NIH HHS; DK-056350/DK/NIDDK NIH HHS; DK-076050/DK/NIDDK NIH HHS; GM-076468/GM/NIGMS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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