| Genetic approaches to studying norepinephrine function: knockout of the mouse norepinephrine transporter gene. | |
| | |
MedLine Citation:
|
PMID: 10560019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Norepinephrine is an important chemical messenger in the nervous system. It regulates affective states, learning and memory, endocrine and autonomic functions. It has been implicated in depression, aggression, and addiction, as well as cardiac and thermal dysregulation. The norepinephrine transporter functions by uptaking norepinephrine back into the cell for cyclic use, and is a direct target of a number of antidepressants and psychostimulants. Functional deletion (knockout) of monamine transporters results in increases in extracellular levels of neurotransmitters, thereby prolonging their actions. For the norepinephrine transporter knockout mice, this altered state of the norepinephrine system should simulate the therapeutic effects of norepinephrine selective antidepressants and some of the effects of psychostimulants. Careful use of such an animal model can hopefully provide valuable insight into the multiple roles norepinephrine plays in normal and pathological physiology. |
| | |
Authors:
|
Y M Wang; F Xu; R R Gainetdinov; M G Caron |
Related Documents
:
|
2648499 - Alcoholics anonymous and contemporary psychodynamic theory. 18532129 - The acoustic role of supralaryngeal air sacs. 21352629 - Experiences of family physicians who practise primary care obstetrics in groups. 21547859 - Pregnant women's fear of childbirth in midwife- and obstetrician-led care in belgium an... 18274969 - Factors affecting the water holding capacity of red meat products: a review of recent r... 11451389 - Handheld digital equipment for weight composite distress paradigms: new considerations ... 16715029 - How will we know patients are safer? an organization-wide approach to measuring and imp... 3985909 - Mechanical ventilation of critically ill newborns on scheduled flights of commercial pa... 15148419 - Molecular diagnostics: future probe-based strategies. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Biological psychiatry Volume: 46 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 1999 Nov |
Date Detail:
|
Created Date: 1999-12-15 Completed Date: 1999-12-15 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1124-30 Citation Subset: IM |
Affiliation:
|
Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Behavior, Addictive / genetics Carrier Proteins / genetics* Depression / genetics Disease Models, Animal* Mice Mice, Knockout* / genetics, metabolism Neurotransmitter Agents / genetics Norepinephrine / biosynthesis, genetics*, metabolism Phenotype |
| Grant Support | |
ID/Acronym/Agency:
|
NS19576/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Carrier Proteins; 0/Neurotransmitter Agents; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: New paths for Internet generated learning in anatomy
Next Document: Molecular control of locus coeruleus neurotransmission.