Document Detail


Genetic approaches to studying norepinephrine function: knockout of the mouse norepinephrine transporter gene.
MedLine Citation:
PMID:  10560019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Norepinephrine is an important chemical messenger in the nervous system. It regulates affective states, learning and memory, endocrine and autonomic functions. It has been implicated in depression, aggression, and addiction, as well as cardiac and thermal dysregulation. The norepinephrine transporter functions by uptaking norepinephrine back into the cell for cyclic use, and is a direct target of a number of antidepressants and psychostimulants. Functional deletion (knockout) of monamine transporters results in increases in extracellular levels of neurotransmitters, thereby prolonging their actions. For the norepinephrine transporter knockout mice, this altered state of the norepinephrine system should simulate the therapeutic effects of norepinephrine selective antidepressants and some of the effects of psychostimulants. Careful use of such an animal model can hopefully provide valuable insight into the multiple roles norepinephrine plays in normal and pathological physiology.
Authors:
Y M Wang; F Xu; R R Gainetdinov; M G Caron
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Biological psychiatry     Volume:  46     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-15     Completed Date:  1999-12-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1124-30     Citation Subset:  IM    
Affiliation:
Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Addictive / genetics
Carrier Proteins / genetics*
Depression / genetics
Disease Models, Animal*
Mice
Mice, Knockout* / genetics,  metabolism
Neurotransmitter Agents / genetics
Norepinephrine / biosynthesis,  genetics*,  metabolism
Phenotype
Grant Support
ID/Acronym/Agency:
NS19576/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Neurotransmitter Agents; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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