Document Detail


Genetic approaches to the study of synaptic plasticity and memory storage.
MedLine Citation:
PMID:  12907923     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Long-term memory is believed to depend on long-lasting changes in the strength of synaptic transmission known as synaptic plasticity. Understanding the molecular mechanisms of long-term synaptic plasticity is one of the principle goals of neuroscience. Among the most powerful tools being brought to bear on this question are genetically modified mice with changes in the expression or biological activity of genes thought to contribute to these processes. This article reviews how strains of mice with alterations in the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate-response element-binding protein signaling pathway have advanced our understanding of the biological basis of learning and memory.
Authors:
Michael P Kaplan; Ted Abel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  CNS spectrums     Volume:  8     ISSN:  1092-8529     ISO Abbreviation:  CNS Spectr     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-08     Completed Date:  2003-12-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9702877     Medline TA:  CNS Spectr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  597-610     Citation Subset:  IM    
Affiliation:
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6018, USA. abele@sas.upenn.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified / genetics
Brain / physiology*
Cyclic AMP Response Element-Binding Protein / genetics
Cyclic AMP-Dependent Protein Kinases / genetics
Humans
Long-Term Potentiation / genetics,  physiology
Mice
Mice, Knockout
Neuronal Plasticity / genetics*
Retention (Psychology) / physiology*
Signal Transduction / genetics*
Synaptic Transmission / genetics*
Grant Support
ID/Acronym/Agency:
HD26979/HD/NICHD NIH HHS; R01 AG18199/AG/NIA NIH HHS; R01 MH60244/MH/NIMH NIH HHS; T32 MH014654/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Cyclic AMP Response Element-Binding Protein; EC 2.7.11.11/Cyclic AMP-Dependent Protein Kinases
Comments/Corrections
Erratum In:
CNS Spectr. 2003 Oct;8(10):719

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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