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Genetic anomalies in mammalian germ cells and their significance for human reproductive and developmental risk.
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MedLine Citation:
PMID:  8243406     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The induction of heritable mutations in germ cells represents a potential health concern. This paper highlights data from mouse germ-cell mutagenesis studies that have implications in the assessment of reproductive and developmental risks. The paper discusses the developmental and reproductive consequences of induced chromosomal damage (structural rearrangements and numerical anomalies) and describes environmental agents that have been shown to produce such anomalies. Additionally, factors that influence the yield of genetic damage are addressed. Studies showing that the various germ-cell stages vary in their susceptibility to the induction of genetic damage are summarized. Of the chemicals evaluated in the male mouse, most appear to have their predominant or strongest effect on post-stem-cell stages. The differences between males and females in the susceptibility to mutagens is examined. Recent studies have shown that the female may be uniquely sensitive to certain mutagens. Finally, an important aspect of mutagenic risk is not only effects induced in developing germ cells but also the effects of environmental agents during the period from fertilization through the zygote and the two-cell embryo. Recent work in the mouse has demonstrated that exposure during these early developmental stages leads to high frequencies of external and visceral fetal malformations, as well as mid-to-late gestational death.
Authors:
V L Dellarco
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Environmental health perspectives     Volume:  101 Suppl 2     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-12-29     Completed Date:  1993-12-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  5-11     Citation Subset:  IM    
Affiliation:
Office of Health and Environmental Assessment (RD-689), U.S. Environmental Protection Agency, Washington, DC 20460.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromosome Aberrations / chemically induced,  genetics*
Chromosome Disorders
Embryonic and Fetal Development / drug effects*
Female
Gene Rearrangement
Germ Cells / drug effects*
Humans
Male
Mice
Mutagens / adverse effects*
Ploidies
Risk Factors
Sex Characteristics
Chemical
Reg. No./Substance:
0/Mutagens
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 7 Year: 1993
Volume: 101 Issue: Suppl 2
First Page: 5 Last Page: 11
ID: 1519935
PubMed Id: 8243406

Genetic anomalies in mammalian germ cells and their significance for human reproductive and developmental risk.
V L Dellarco
Office of Health and Environmental Assessment (RD-689), U.S. Environmental Protection Agency, Washington, DC 20460.



Article Categories:
  • Research Article


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