| Genetic ancestry and risk factors for breast cancer among Latinas in the San Francisco Bay Area. | |
| | |
MedLine Citation:
|
PMID: 17035394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Genetic association studies using case-control designs are susceptible to false-positive and false-negative results if there are differences in genetic ancestry between cases and controls. We measured genetic ancestry among Latinas in a population-based case-control study of breast cancer and tested the association between ancestry and known breast cancer risk factors. We reasoned that if genetic ancestry is associated with known breast cancer risk factors, then the results of genetic association studies would be confounded. METHODS: We used 44 ancestry informative markers to estimate individuals' genetic ancestry in 563 Latina participants. To test whether ancestry is a predictor of hormone therapy use, parity, and body mass index (BMI), we used multivariate logistic regression models to estimate odds ratios (OR) and 95% confidence intervals (95% CI) associated with a 25% increase in Indigenous American ancestry, adjusting for age, education, and the participant's and grandparents' place of birth. RESULTS: Hormone therapy use was significantly less common among women with higher Indigenous American ancestry (OR, 0.78; 95% CI, 0.63-0.96). Higher Indigenous American ancestry was also significantly associated with overweight (BMI, 25-29.9 versus <25) and obesity (BMI, > or =30 versus <25), but only among foreign-born Latina women (OR, 3.44; 95% CI, 1.97-5.99 and OR, 1.95; 95% CI, 1.24-3.06, respectively). CONCLUSION: Some breast cancer risk factors are associated with genetic ancestry among Latinas in the San Francisco Bay Area. Therefore, case-control genetic association studies for breast cancer should directly measure genetic ancestry to avoid potential confounding. |
| | |
Authors:
|
Elad Ziv; Esther M John; Shweta Choudhry; Jennifer Kho; Wendy Lorizio; Eliseo J Perez-Stable; Esteban Gonzalez Burchard |
Related Documents
:
|
10850134 - The epidemiology of her-2/neu and p53 in breast cancer. 19444084 - Breast cancer risk perception and lifestyle behaviors among white and black women with ... 19009364 - Breast cancer risk and hysterectomy status: the multiethnic cohort study. 15996484 - Hormonal and body-size factors in relation to breast cancer risk: a prospective study o... 12223434 - Genetic polymorphism of cyp2a6 gene and tobacco-induced lung cancer risk in male smokers. 2910524 - Neuroendocrine dysdifferentiation and bombesin production in carcinogen-induced hepatoc... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Volume: 15 ISSN: 1055-9965 ISO Abbreviation: Cancer Epidemiol. Biomarkers Prev. Publication Date: 2006 Oct |
Date Detail:
|
Created Date: 2006-10-12 Completed Date: 2007-06-20 Revised Date: 2011-11-29 |
Medline Journal Info:
|
Nlm Unique ID: 9200608 Medline TA: Cancer Epidemiol Biomarkers Prev Country: United States |
Other Details:
|
Languages: eng Pagination: 1878-85 Citation Subset: IM |
Affiliation:
|
Division of General Internal Medicine, University of California San Francisco, Box 1732, San Francisco, CA 94143, USA. elad.ziv@ucsf.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult African Americans / genetics Aged Aged, 80 and over Breast Neoplasms / ethnology*, etiology*, genetics Case-Control Studies Emigration and Immigration European Continental Ancestry Group / genetics Female Genetic Markers Genetic Predisposition to Disease / ethnology Genotype Hispanic Americans / genetics*, statistics & numerical data Humans Logistic Models Middle Aged Multivariate Analysis Obesity / complications, ethnology Population Surveillance Predictive Value of Tests Risk Assessment Risk Factors San Francisco / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
|
K22 CA109351-03/CA/NCI NIH HHS; K22CA109351/CA/NCI NIH HHS; R01 CA063446-04/CA/NCI NIH HHS; R01 CA077305-03/CA/NCI NIH HHS; U01 CA069417-10/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Genetic Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: General and abdominal obesity and survival among young women with breast cancer.
Next Document: Increases in plasma carotenoid concentrations in response to a major dietary change in the women's h...