Document Detail


Genetic analysis of viral variants selected in transmission of human immunodeficiency viruses to newborns.
MedLine Citation:
PMID:  10957720     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our previous studies have indicated that HIV transmission from infected mothers to infants occurs with viruses showing rapid kinetics of replication, and either resistance to maternal neutralizing antibodies or sensitivity to enhancing antibodies. The genotypic patterns that result in these and other phenotypic viral characteristics may provide clues to the selection pressures exerted during this mode of transmission. For this reason, DNA sequences of the envelope gene (env) were determined for viral isolates obtained from seropositive women who were mothers of either infected or uninfected infants. Sequences of viruses isolated early in life from the infected newborns were also determined, such that diversity both within isolates and between maternal and infant isolates could be assessed. Among isolates obtained from mothers of uninfected infants, the V3 region of env demonstrated a higher degree of heterogeneity than those from mothers of infected infants. Similar to the viruses obtained from the mothers of infected infants, the infant-derived viral sequences were relatively homogeneous. Finally, the reactivity of maternal plasma with infant-derived HIV isolates, whether via neutralizing or enhancing antibodies, appeared to predict the distribution of viral sequences in the infant isolates. These data suggest that selective pressure on HIV-1 during transmission or growth in the infected infant may be mediated by biologic and/or immunologic processes.
Authors:
S Kliks; C H Contag; H Corliss; G Learn; A Rodrigo; D Wara; J I Mullins; J A Levy
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  16     ISSN:  0889-2229     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-09-27     Completed Date:  2000-09-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1223-33     Citation Subset:  IM; X    
Affiliation:
Cancer Research Institute and Department of Pediatrics, School of Medicine, University of California, San Francisco 94143, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AF250620;  AF250621;  AF250622;  AF250623;  AF250624;  AF250625;  AF250626;  AF250627;  AF250628;  AF250629;  AF250630;  AF250631;  AF250632;  AF250633;  AF250634;  AF250635;  AF250636;  AF250637;  AF250638;  AF250639;  AF250640;  AF250641;  AF250642;  AF250643;  AF250644;  AF250645;  AF250646;  AF250647;  AF250648;  AF250649
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MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acid Sequence
Base Sequence
DNA, Viral / blood
Female
Genetic Variation / genetics*
HIV Antibodies / blood
HIV Envelope Protein gp120 / genetics
HIV Infections / transmission*,  virology
HIV-1 / genetics*,  isolation & purification,  physiology*
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical*
Molecular Sequence Data
Peptide Fragments / genetics
Sequence Analysis, DNA
Grant Support
ID/Acronym/Agency:
R01 AI32446-01/AI/NIAID NIH HHS; R01 AI32885/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Viral; 0/HIV Antibodies; 0/HIV Envelope Protein gp120; 0/HIV envelope protein gp120 (305-321); 0/Peptide Fragments

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