Document Detail


Genetic analysis of tongue size and taste papillae number and size in recombinant inbred strains of mice.
MedLine Citation:
PMID:  18653645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quantitative trait loci (QTLs) analysis has been used to examine natural variation of phenotypes in the mouse somatosensory cortex, hippocampus, cerebellum, and amygdala. QTL analysis has also been utilized to map and identify genes underlying anatomical features such as muscle, organ, and body weights. However, this methodology has not been previously applied to identification of anatomical structures related to gustatory phenotypes. In this study, we used QTL analysis to map and characterize genes underlying tongue size, papillae number, and papillae area. In a set of 43 BXD recombinant inbred (RI) mice (n = 111) and 2 parental strains (C57BL/6J and DBA/2J; n = 7), we measured tongue length, width, and weight. In a subset of 23 BXD RI mice and the parental mice, we measured filiform and fungiform papillae number and fungiform papillae area. Using QTL linkage analysis (through WebQTL), we detected 2 significant and noninteracting QTLs influencing tongue length on chromosomes 5 and 7. We also found a significant QTL on chromosome 19 underlying fungiform papillae area and a suggestive QTL on chromosome 2 linked to fungiform papillae number. From these QTLs, we identified a number of candidate genes within the QTL intervals that include SRY-box containing gene, nebulin-related anchoring protein, and actin-binding LIM protein 1. This study is an important first step in identifying genetic factors underlying tongue size, papillae size, and papillae number using QTL analysis.
Authors:
David J Reiner; Taha A Jan; John D Boughter; Cheng-Xiang Li; Lu Lu; Robert W Williams; Robert S Waters
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-07-24
Journal Detail:
Title:  Chemical senses     Volume:  33     ISSN:  1464-3553     ISO Abbreviation:  Chem. Senses     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-13     Completed Date:  2009-03-24     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  8217190     Medline TA:  Chem Senses     Country:  England    
Other Details:
Languages:  eng     Pagination:  693-707     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, College of Medicine, 855 Monroe Avenue, Memphis, TN 38163, USA.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology
Animals
Body Weight
Cell Count
Cell Size
Dental Papilla / anatomy & histology,  metabolism
Female
Genome / genetics
Male
Mice
Mice, Inbred Strains
Organ Size
Phenotype
Quantitative Trait Loci / genetics
Recombination, Genetic / genetics*
Sex Characteristics
Taste Buds / cytology*,  metabolism*
Tongue / anatomy & histology*,  metabolism*
Grant Support
ID/Acronym/Agency:
5R01DC000066/DC/NIDCD NIH HHS; NS052366/NS/NINDS NIH HHS
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