Document Detail

Genetic analysis of murine strains C57BL/6J and C3H/HeJ to confirm the map position of Ath-1, a gene determining atherosclerosis susceptibility.
MedLine Citation:
PMID:  3128974     Owner:  NLM     Status:  MEDLINE    
Previous results suggested that strains C57BL/6J and C3H/HeJ differed in a single gene for atherosclerosis susceptibility, called Ath-1. Based on data from recombinant inbred strains Ath-1 was tentatively assigned to chromosome 1 linked to Alp-2. In this report, a cross between C57BL/6 and C3H/HeJ was carried out in order to test whether the tentative map position was correct. Parental strains and F1 and F2 progeny were examined. Susceptible alleles of Ath-1, found in C57BL/6, are associated with relatively low levels of high-density lipoprotein (HDL)-cholesterol in animals fed an atherogenic diet; resistant alleles of Ath-1 are associated with relatively high levels of HDL-cholesterol. F1 progeny have HDL levels that are intermediate between these of the two parental strains. Among the F2 progeny, Alp-2 and Ath-1 cosegregated, providing confirmatory evidence that Ath-1 is linked to Alp-2 on chromosome 1. Three mice recombinant for Alp-2 and Ath-1 were found among the 60 chromosomes tested, giving an estimated map distance between these two genes of 5.0 +/- 2.8 (SE) cM. The phenotypic characteristics of Ath-1 resemble a genetic trait in humans, hyperalphalipoproteinemia, which is characterized by elevated levels of HDL-cholesterol, reduced risk of heart disease, and increased longevity.
B Paigen; D Albee; P A Holmes; D Mitchell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical genetics     Volume:  25     ISSN:  0006-2928     ISO Abbreviation:  Biochem. Genet.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1988-05-20     Completed Date:  1988-05-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0126611     Medline TA:  Biochem Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  501-11     Citation Subset:  IM    
Bruce Lyon Memorial Research Laboratory, Children's Hospital Medical Center, Oakland, California 94609.
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MeSH Terms
Aorta / pathology
Apolipoprotein A-II
Apolipoproteins A / blood
Arteriosclerosis / genetics*,  veterinary
Chromosome Mapping*
Crosses, Genetic
Genetic Predisposition to Disease
Isoelectric Focusing
Lipoproteins, HDL / blood
Mice, Inbred C3H / genetics*
Mice, Inbred C57BL / genetics*
Rodent Diseases / genetics
Grant Support
Reg. No./Substance:
0/Apolipoprotein A-II; 0/Apolipoproteins A; 0/Lipoproteins, HDL

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