Document Detail

Genetic analysis of left-right coordination of locomotion .
MedLine Citation:
PMID:  23276907     Owner:  NLM     Status:  MEDLINE    
While there is a rather large amount of data from pharmacological and anatomical studies of the murine locomotor CPG network, comprehensive information regarding the cellular and functional properties of the neuronal populations is lacking. Here we describe concepts arising from genetic studies of the locomotor network with a focus on commissural interneurons regulating left-right coordination. In particular, this involves several families of axon guidance molecules relevant for midline crossing. We also describe recent advances within the field of neural circuit analysis, including imaging, genetic inactivation and optogenetic strategies, which are applicable to locomotor circuits. Such efforts, for example by using available genetic markers, should substantially increase our possibilities to decipher the functionality of spinal cord neuronal networks.
Nadine Rabe Bernhardt; Fatima Memic; Klas Kullander
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-35     Citation Subset:  IM    
Department of Neuroscience, Uppsala University, Box 593, 751 24 Uppsala, Sweden.
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MeSH Terms
Axons / physiology
Functional Laterality / genetics*,  physiology
Intercellular Signaling Peptides and Proteins / genetics
Interneurons / physiology*
Locomotion / genetics,  physiology*
Nerve Growth Factors / physiology
Nerve Net / embryology,  physiology
Nerve Tissue Proteins / genetics
Receptors, Eph Family / physiology
Receptors, Immunologic / genetics
Semaphorins / physiology
Signal Transduction
Spinal Cord / embryology,  physiology
Tumor Suppressor Proteins / physiology
Reg. No./Substance:
0/Intercellular Signaling Peptides and Proteins; 0/Nerve Growth Factors; 0/Nerve Tissue Proteins; 0/Receptors, Immunologic; 0/Semaphorins; 0/Slit homolog 2 protein; 0/Tumor Suppressor Proteins; 0/roundabout protein; 158651-98-0/netrin-1; EC, Eph Family

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